Targeting macrophage phenotypes to prevent diseases caused by Leishmania and Trypanosoma cruzi infections

Targeting macrophage phenotypes to prevent diseases caused by Leishmania and Trypanosoma cruzi infections

Macrophage plasticity is remarkable, and recent studies have opened new prophylactic and therapeutic avenues for immunomodulation of macrophage phenotypes in inflammatory and infectious diseases. During infections caused by the pathogenic protozoans Leishmania spp. and Trypanosoma cruzi, susceptibil...

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Bibliographic Details
Main Authors: Natália S. Vellozo, Thayane C. Matos-Silva, Marcela F. Lopes
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
ATRA
Axl
Chagas disease
efferocytosis
Leishmaniasis
M1 and M2 macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1595954/full
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