FAMILIAL MEDITERRANEAN FEVER AND HYPERCOAGULABILITY
<span lang="EN-US" style="font-family: ">Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease which is characterized by recurrent attacks of fever and peritonitis, pleuritis, arthritis, or erysipelas-like skin disease. As such, FMF is a pr...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2011-01-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/article/view/7861 |
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| author | Oshrat E. Tayer-Shifman Eldad Ben-Chetrit |
| author_facet | Oshrat E. Tayer-Shifman Eldad Ben-Chetrit |
| author_sort | Oshrat E. Tayer-Shifman |
| collection | DOAJ |
| description | <span lang="EN-US" style="font-family: ">Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease which is characterized by recurrent attacks of fever and peritonitis, pleuritis, arthritis, or erysipelas-like skin disease. As such, FMF is a prototype of autoinflammatory diseases where genetic changes lead to acute inflammatory episodes</span><strong><span lang="EN-US" style="font-family: ">.</span></strong><span lang="EN-US" style="font-family: "> Systemic inflammation – in general - may increase procoagulant factors, and decrease natural anticoagulants and fibrinolytic activity</span><strong><span lang="EN-US" style="font-family: ">.</span></strong><span lang="EN-US" style="font-family: "> Therefore, it is anticipated to see more thrombotic events among FMF patients compared with healthy subjects</span><strong><span lang="EN-US" style="font-family: ">.</span></strong><span lang="EN-US" style="font-family: "> However, reviewing the current available literature and based upon our personal experience, thrombotic events related purely to FMF are very rare</span><strong><span lang="EN-US" style="font-family: ">.</span></strong><span lang="EN-US" style="font-family: "> Possible explanation for this discrepancy is that along with the procoagulant activity during FMF acute attacks, anticoagulant and fibrinolytic changes are <strong>also</strong> taking place</span><strong><span lang="EN-US" style="font-family: ">.</span></strong><span lang="EN-US" style="font-family: "> Furthermore, it may well be that during the acute attack of FMF the procoagulant factors are consumed or used for the purpose of inflammation so that nothing is left for their role in the coagulation pathway</span><strong><span lang="EN-US" style="font-family: ">. </span></strong><span lang="EN-US" style="font-family: ">Colchicine may also play a role in reducing inflammation thereby decreasing hypercoagulabilty</span> |
| format | Article |
| id | doaj-art-a17e4631af4d40f38db3c77ff4790fd1 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-a17e4631af4d40f38db3c77ff4790fd12025-01-02T01:52:13ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062011-01-0131e2011017e2011017FAMILIAL MEDITERRANEAN FEVER AND HYPERCOAGULABILITYOshrat E. Tayer-ShifmanEldad Ben-Chetrit<span lang="EN-US" style="font-family: ">Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease which is characterized by recurrent attacks of fever and peritonitis, pleuritis, arthritis, or erysipelas-like skin disease. As such, FMF is a prototype of autoinflammatory diseases where genetic changes lead to acute inflammatory episodes</span><strong><span lang="EN-US" style="font-family: ">.</span></strong><span lang="EN-US" style="font-family: "> Systemic inflammation – in general - may increase procoagulant factors, and decrease natural anticoagulants and fibrinolytic activity</span><strong><span lang="EN-US" style="font-family: ">.</span></strong><span lang="EN-US" style="font-family: "> Therefore, it is anticipated to see more thrombotic events among FMF patients compared with healthy subjects</span><strong><span lang="EN-US" style="font-family: ">.</span></strong><span lang="EN-US" style="font-family: "> However, reviewing the current available literature and based upon our personal experience, thrombotic events related purely to FMF are very rare</span><strong><span lang="EN-US" style="font-family: ">.</span></strong><span lang="EN-US" style="font-family: "> Possible explanation for this discrepancy is that along with the procoagulant activity during FMF acute attacks, anticoagulant and fibrinolytic changes are <strong>also</strong> taking place</span><strong><span lang="EN-US" style="font-family: ">.</span></strong><span lang="EN-US" style="font-family: "> Furthermore, it may well be that during the acute attack of FMF the procoagulant factors are consumed or used for the purpose of inflammation so that nothing is left for their role in the coagulation pathway</span><strong><span lang="EN-US" style="font-family: ">. </span></strong><span lang="EN-US" style="font-family: ">Colchicine may also play a role in reducing inflammation thereby decreasing hypercoagulabilty</span>http://www.mjhid.org/article/view/7861Mediterranean Fever , Hypercoagulable Syùtae , Thrombophilia |
| spellingShingle | Oshrat E. Tayer-Shifman Eldad Ben-Chetrit FAMILIAL MEDITERRANEAN FEVER AND HYPERCOAGULABILITY Mediterranean Journal of Hematology and Infectious Diseases Mediterranean Fever , Hypercoagulable Syùtae , Thrombophilia |
| title | FAMILIAL MEDITERRANEAN FEVER AND HYPERCOAGULABILITY |
| title_full | FAMILIAL MEDITERRANEAN FEVER AND HYPERCOAGULABILITY |
| title_fullStr | FAMILIAL MEDITERRANEAN FEVER AND HYPERCOAGULABILITY |
| title_full_unstemmed | FAMILIAL MEDITERRANEAN FEVER AND HYPERCOAGULABILITY |
| title_short | FAMILIAL MEDITERRANEAN FEVER AND HYPERCOAGULABILITY |
| title_sort | familial mediterranean fever and hypercoagulability |
| topic | Mediterranean Fever , Hypercoagulable Syùtae , Thrombophilia |
| url | http://www.mjhid.org/article/view/7861 |
| work_keys_str_mv | AT oshratetayershifman familialmediterraneanfeverandhypercoagulability AT eldadbenchetrit familialmediterraneanfeverandhypercoagulability |