A case of hypoparathyroidism with cardiovascular complications: interventricular septal dissecting aneurysm in a middle-aged woman
Abstract Background Hypoparathyroidism (HypoPT) is a rare endocrine disease characterized by hypocalcemia, hyperphosphatemia, and insufficient or no parathyroid hormone (PTH) secretion. Hypoparathyroidism-induced chronic hypocalcemia may lead to cardiovascular complications, including myocardial dys...
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BMC
2025-07-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-025-02009-9 |
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| author | Ronghua Huang Yi Zhou Xingshou Pan Liufang Zhou Zhengjiang Liu |
| author_facet | Ronghua Huang Yi Zhou Xingshou Pan Liufang Zhou Zhengjiang Liu |
| author_sort | Ronghua Huang |
| collection | DOAJ |
| description | Abstract Background Hypoparathyroidism (HypoPT) is a rare endocrine disease characterized by hypocalcemia, hyperphosphatemia, and insufficient or no parathyroid hormone (PTH) secretion. Hypoparathyroidism-induced chronic hypocalcemia may lead to cardiovascular complications, including myocardial dysfunction and arrhythmias. Interventricular septal dissecting aneurysm, a rare cardiac anomaly, typically arises following structural or ischemic heart disease. This disease can lead to ventricular septal rupture and aneurysmal cystic chamber formation, causing changes in cardiac structure and hemodynamics as well as giving rise to various heart complications. Case presentation No study has reported an association between hypocalcemia and cardiac masses. We encountered a case of hypoparathyroidism in a middle-aged woman who developed an interventricular septal dissecting aneurysm. Upon examination, we found that HypoPT has a profound impact on the heart. Conclusions Hypocalcemia caused by HypoPT can result in structural changes in the heart and myocardial injury. Furthermore, there is a potential link between HypoPT and cardiac aneurysm. The development of an interventricular septal dissecting aneurysm can lead to various cardiac complications; therefore, its early diagnosis and treatment are necessary. |
| format | Article |
| id | doaj-art-a170a0d5b0c74d5c8462ae6b51cc30cf |
| institution | Kabale University |
| issn | 1472-6823 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-a170a0d5b0c74d5c8462ae6b51cc30cf2025-08-20T03:45:57ZengBMCBMC Endocrine Disorders1472-68232025-07-012511710.1186/s12902-025-02009-9A case of hypoparathyroidism with cardiovascular complications: interventricular septal dissecting aneurysm in a middle-aged womanRonghua Huang0Yi Zhou1Xingshou Pan2Liufang Zhou3Zhengjiang Liu4Department of Cardiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Youjiang Medical University for NationalitiesDepartment of Cardiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Youjiang Medical University for NationalitiesDepartment of Cardiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Youjiang Medical University for NationalitiesDepartment of Cardiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Youjiang Medical University for NationalitiesDepartment of Cardiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Youjiang Medical University for NationalitiesAbstract Background Hypoparathyroidism (HypoPT) is a rare endocrine disease characterized by hypocalcemia, hyperphosphatemia, and insufficient or no parathyroid hormone (PTH) secretion. Hypoparathyroidism-induced chronic hypocalcemia may lead to cardiovascular complications, including myocardial dysfunction and arrhythmias. Interventricular septal dissecting aneurysm, a rare cardiac anomaly, typically arises following structural or ischemic heart disease. This disease can lead to ventricular septal rupture and aneurysmal cystic chamber formation, causing changes in cardiac structure and hemodynamics as well as giving rise to various heart complications. Case presentation No study has reported an association between hypocalcemia and cardiac masses. We encountered a case of hypoparathyroidism in a middle-aged woman who developed an interventricular septal dissecting aneurysm. Upon examination, we found that HypoPT has a profound impact on the heart. Conclusions Hypocalcemia caused by HypoPT can result in structural changes in the heart and myocardial injury. Furthermore, there is a potential link between HypoPT and cardiac aneurysm. The development of an interventricular septal dissecting aneurysm can lead to various cardiac complications; therefore, its early diagnosis and treatment are necessary.https://doi.org/10.1186/s12902-025-02009-9HypoparathyroidismInterventricular septal aneurysmCardiovascular diseaseParathyroid hormone |
| spellingShingle | Ronghua Huang Yi Zhou Xingshou Pan Liufang Zhou Zhengjiang Liu A case of hypoparathyroidism with cardiovascular complications: interventricular septal dissecting aneurysm in a middle-aged woman BMC Endocrine Disorders Hypoparathyroidism Interventricular septal aneurysm Cardiovascular disease Parathyroid hormone |
| title | A case of hypoparathyroidism with cardiovascular complications: interventricular septal dissecting aneurysm in a middle-aged woman |
| title_full | A case of hypoparathyroidism with cardiovascular complications: interventricular septal dissecting aneurysm in a middle-aged woman |
| title_fullStr | A case of hypoparathyroidism with cardiovascular complications: interventricular septal dissecting aneurysm in a middle-aged woman |
| title_full_unstemmed | A case of hypoparathyroidism with cardiovascular complications: interventricular septal dissecting aneurysm in a middle-aged woman |
| title_short | A case of hypoparathyroidism with cardiovascular complications: interventricular septal dissecting aneurysm in a middle-aged woman |
| title_sort | case of hypoparathyroidism with cardiovascular complications interventricular septal dissecting aneurysm in a middle aged woman |
| topic | Hypoparathyroidism Interventricular septal aneurysm Cardiovascular disease Parathyroid hormone |
| url | https://doi.org/10.1186/s12902-025-02009-9 |
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