Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5, 10-dione derivatives using Hercynite magnetic nanocatalyst
Pyrazolophthalazines and their derivatives are known as a substance with diverse chemical and biological activity. These compounds have various medicinal properties such as anti-bacterial, anti-viral, anti-coagulant and anti-cancer. In this research synthesis of Pyrazolo-phthalazine derivatives by r...
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Semnan University
2024-06-01
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| Series: | شیمی کاربردی روز |
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| Online Access: | https://chemistry.semnan.ac.ir/article_8832_d0f13fa92009d17e952ed903490be46f.pdf |
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| author | Zahra Paknejadi Hassan Kefayati |
| author_facet | Zahra Paknejadi Hassan Kefayati |
| author_sort | Zahra Paknejadi |
| collection | DOAJ |
| description | Pyrazolophthalazines and their derivatives are known as a substance with diverse chemical and biological activity. These compounds have various medicinal properties such as anti-bacterial, anti-viral, anti-coagulant and anti-cancer. In this research synthesis of Pyrazolo-phthalazine derivatives by reaction of aromatic aldehyde derivatives, Phthalic hydrazide and malononitrile in the presence of Hercynite as nano-catalyst were studied and the products were obtained in 45-90 minutes with yield of 90-97%. The structure of Hercynite nanocatalyst was investigated using FT-IR and SEM methods and X-ray diffraction pattern. The results of the morphology of the nanocatalyst surface show that the nanoparticles are spherical and the size of the particles is between 49-80 nm. Investigating the magnetic property of the catalyst with VSM analysis shows the favorable magnetic property of Hercynite nanocatalyst for its separation with an external magnetic field. Easy operation, high efficiency, reuse of the catalyst for several times, short reaction time and easy separation of the catalyst using an external magnet are the most important advantages of the presented method. |
| format | Article |
| id | doaj-art-a1657a4a8bde4f4f87b548819cb33d57 |
| institution | Kabale University |
| issn | 2981-2437 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Semnan University |
| record_format | Article |
| series | شیمی کاربردی روز |
| spelling | doaj-art-a1657a4a8bde4f4f87b548819cb33d572024-12-09T08:30:34ZengSemnan Universityشیمی کاربردی روز2981-24372024-06-01197118320010.22075/chem.2024.30688.21778832Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5, 10-dione derivatives using Hercynite magnetic nanocatalystZahra Paknejadi0Hassan Kefayati1Chemistry department, Islamic Azad University, Rasht, BranchChemistry department, Isalmic Azad University, Rasht BranchPyrazolophthalazines and their derivatives are known as a substance with diverse chemical and biological activity. These compounds have various medicinal properties such as anti-bacterial, anti-viral, anti-coagulant and anti-cancer. In this research synthesis of Pyrazolo-phthalazine derivatives by reaction of aromatic aldehyde derivatives, Phthalic hydrazide and malononitrile in the presence of Hercynite as nano-catalyst were studied and the products were obtained in 45-90 minutes with yield of 90-97%. The structure of Hercynite nanocatalyst was investigated using FT-IR and SEM methods and X-ray diffraction pattern. The results of the morphology of the nanocatalyst surface show that the nanoparticles are spherical and the size of the particles is between 49-80 nm. Investigating the magnetic property of the catalyst with VSM analysis shows the favorable magnetic property of Hercynite nanocatalyst for its separation with an external magnetic field. Easy operation, high efficiency, reuse of the catalyst for several times, short reaction time and easy separation of the catalyst using an external magnet are the most important advantages of the presented method.https://chemistry.semnan.ac.ir/article_8832_d0f13fa92009d17e952ed903490be46f.pdfhercynitemalononitrilepyrazolo-phthalazinenano-catalystphthalic hydrazide |
| spellingShingle | Zahra Paknejadi Hassan Kefayati Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5, 10-dione derivatives using Hercynite magnetic nanocatalyst شیمی کاربردی روز hercynite malononitrile pyrazolo-phthalazine nano-catalyst phthalic hydrazide |
| title | Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5, 10-dione derivatives using Hercynite magnetic nanocatalyst |
| title_full | Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5, 10-dione derivatives using Hercynite magnetic nanocatalyst |
| title_fullStr | Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5, 10-dione derivatives using Hercynite magnetic nanocatalyst |
| title_full_unstemmed | Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5, 10-dione derivatives using Hercynite magnetic nanocatalyst |
| title_short | Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5, 10-dione derivatives using Hercynite magnetic nanocatalyst |
| title_sort | synthesis of 1h pyrazolo 1 2 b phthalazine 5 10 dione derivatives using hercynite magnetic nanocatalyst |
| topic | hercynite malononitrile pyrazolo-phthalazine nano-catalyst phthalic hydrazide |
| url | https://chemistry.semnan.ac.ir/article_8832_d0f13fa92009d17e952ed903490be46f.pdf |
| work_keys_str_mv | AT zahrapaknejadi synthesisof1hpyrazolo12bphthalazine510dionederivativesusinghercynitemagneticnanocatalyst AT hassankefayati synthesisof1hpyrazolo12bphthalazine510dionederivativesusinghercynitemagneticnanocatalyst |