Significant association between three atherosclerosis indexes and stroke risk.
<h4>Background</h4>To evaluate the associations of three atherosclerosis indexes with stroke in a population aged 65 years and older.<h4>Methods</h4>A sample was obtained from wave 2011 to wave 2015 of the China Health and Retirement Longitudinal Study. Multivariate logistic...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0315396 |
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| Summary: | <h4>Background</h4>To evaluate the associations of three atherosclerosis indexes with stroke in a population aged 65 years and older.<h4>Methods</h4>A sample was obtained from wave 2011 to wave 2015 of the China Health and Retirement Longitudinal Study. Multivariate logistic regression models were used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for stroke in the quartiles of three atherosclerosis indexes, and restricted cubic splines were constructed.<h4>Results</h4>Four hundred and fifty-four of the 21,913 eligible participants had stroke. After multivariate adjustments and with respect to the lowest quartiles, the ORs (95% CIs) of stroke in the highest quartiles of the atherogenic index of plasma (AIP), the Castelli risk index I (CRI-I), and the Castelli risk index II (CRI-II) were 1.35 (0.99-1.83), 1.52 (1.13-2.06), and 1.40 (1.05-1.86), respectively. When assessed as a continuous exposure, per-unit increases in the AIP, CRI-I, and CRI-II were independently associated with a 49% (OR: 1.49, 95% CI: 1.07-2.08), 6% (OR: 1.06, 95% CI: 1.02-1.11), and 14% (OR: 1.14, 95% CI: 1.03-1.27) increase in the risk of stroke, respectively.<h4>Conclusion</h4>The three atherosclerosis indexes studied-the AIP, CRI-I, and CRI-II-were found to be predictors of stroke in a Chinese population. |
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| ISSN: | 1932-6203 |