Effect of taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus on clinical manifestations of functional dyspepsia and patients’ quality of life
Background. Functional dyspepsia is a common disorder that is difficult to treat and has a significant negative impact on the quality of life of patients. There is growing evidence that small intestinal microbiota plays a certain role in the pathophysiology of functional dyspepsia. Research aim: to...
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Zaslavsky O.Yu.
2024-12-01
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| Series: | Gastroenterologìa |
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| Online Access: | https://gastro.zaslavsky.com.ua/index.php/journal/article/view/634 |
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| author | I.G. Paliy S.V. Zaika O.O. Ksenchyn I.V. Chernova |
| author_facet | I.G. Paliy S.V. Zaika O.O. Ksenchyn I.V. Chernova |
| author_sort | I.G. Paliy |
| collection | DOAJ |
| description | Background. Functional dyspepsia is a common disorder that is difficult to treat and has a significant negative impact on the quality of life of patients. There is growing evidence that small intestinal microbiota plays a certain role in the pathophysiology of functional dyspepsia. Research aim: to study the effect of a product containing lyophilized lactic acid bacteria Lactobacillus delbrueckii subsp. bulgaricus strain 9702 (IMV B-7085) and its metabolic products on the clinical manifestations of the disease and quality of life of patients with functional dyspepsia. Materials and methods. Thirty-seven patients (16 men and 21 women) with functional dyspepsia were included in the study, their average age was (45.9 ± 2.5) years. The score on the Gastrointestinal Symptom Rating Scale was analyzed before treatment, after completing a 15-day course of taking the probiotic additive, which contained Lactobacillus delbrueckii subsp. bulgaricus, and 15 days after the end of the course. The dynamics of quality of life was evaluated based on the analysis of the SF-36 questionnaires, completed by patients before treatment and on day 30 of observation. Statistical calculations were performed using MedCalc® software, version 12.5.0.0. Results. On day 15 of taking the drug and 15 days after the end of the course, a significant (p < 0.05) decrease in the severity of clinical manifestations on the Gastrointestinal Symptom Rating Scale was found compared to the baseline. The analysis of the dynamics of responses to the SF-36 questionnaire revealed a significant increase (p < 0.05) on all scales of the physical component of health and a significant increase (p < 0.05) in social functioning on all scales of the psychological component of health on day 30 of observation. Conclusions. Taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus strain 9702 (IMV B-7085) improves the clinical manifestations of functional dyspepsia, as evidenced by a reduction in the severity of gastrointestinal symptoms and increased quality of life of these patients. |
| format | Article |
| id | doaj-art-a15b337e7a144b12ae63000016874d84 |
| institution | Kabale University |
| issn | 2308-2097 2518-7880 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Gastroenterologìa |
| spelling | doaj-art-a15b337e7a144b12ae63000016874d842025-01-12T12:37:32ZengZaslavsky O.Yu.Gastroenterologìa2308-20972518-78802024-12-0158424024510.22141/2308-2097.58.4.2024.634634Effect of taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus on clinical manifestations of functional dyspepsia and patients’ quality of lifeI.G. Paliy0https://orcid.org/0000-0002-9874-6825S.V. Zaika1https://orcid.org/0000-0002-3954-4537O.O. Ksenchyn2https://orcid.org/0000-0001-8438-5320I.V. Chernova3https://orcid.org/0009-0009-5690-7385Vinnytsya National Pirogov Memorial Medical University, Vinnytsia, UkraineVinnytsya National Pirogov Memorial Medical University, Vinnytsia, UkraineVinnytsya National Pirogov Memorial Medical University, Vinnytsia, UkraineVinnytsya National Pirogov Memorial Medical University, Vinnytsia, UkraineBackground. Functional dyspepsia is a common disorder that is difficult to treat and has a significant negative impact on the quality of life of patients. There is growing evidence that small intestinal microbiota plays a certain role in the pathophysiology of functional dyspepsia. Research aim: to study the effect of a product containing lyophilized lactic acid bacteria Lactobacillus delbrueckii subsp. bulgaricus strain 9702 (IMV B-7085) and its metabolic products on the clinical manifestations of the disease and quality of life of patients with functional dyspepsia. Materials and methods. Thirty-seven patients (16 men and 21 women) with functional dyspepsia were included in the study, their average age was (45.9 ± 2.5) years. The score on the Gastrointestinal Symptom Rating Scale was analyzed before treatment, after completing a 15-day course of taking the probiotic additive, which contained Lactobacillus delbrueckii subsp. bulgaricus, and 15 days after the end of the course. The dynamics of quality of life was evaluated based on the analysis of the SF-36 questionnaires, completed by patients before treatment and on day 30 of observation. Statistical calculations were performed using MedCalc® software, version 12.5.0.0. Results. On day 15 of taking the drug and 15 days after the end of the course, a significant (p < 0.05) decrease in the severity of clinical manifestations on the Gastrointestinal Symptom Rating Scale was found compared to the baseline. The analysis of the dynamics of responses to the SF-36 questionnaire revealed a significant increase (p < 0.05) on all scales of the physical component of health and a significant increase (p < 0.05) in social functioning on all scales of the psychological component of health on day 30 of observation. Conclusions. Taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus strain 9702 (IMV B-7085) improves the clinical manifestations of functional dyspepsia, as evidenced by a reduction in the severity of gastrointestinal symptoms and increased quality of life of these patients.https://gastro.zaslavsky.com.ua/index.php/journal/article/view/634functional dyspepsialactobacillus delbrueckii subsp. bulgaricusgastrointestinal symptom rating scalequality of life |
| spellingShingle | I.G. Paliy S.V. Zaika O.O. Ksenchyn I.V. Chernova Effect of taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus on clinical manifestations of functional dyspepsia and patients’ quality of life Gastroenterologìa functional dyspepsia lactobacillus delbrueckii subsp. bulgaricus gastrointestinal symptom rating scale quality of life |
| title | Effect of taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus on clinical manifestations of functional dyspepsia and patients’ quality of life |
| title_full | Effect of taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus on clinical manifestations of functional dyspepsia and patients’ quality of life |
| title_fullStr | Effect of taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus on clinical manifestations of functional dyspepsia and patients’ quality of life |
| title_full_unstemmed | Effect of taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus on clinical manifestations of functional dyspepsia and patients’ quality of life |
| title_short | Effect of taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus on clinical manifestations of functional dyspepsia and patients’ quality of life |
| title_sort | effect of taking a dietary supplement containing lactobacillus delbrueckii subsp bulgaricus on clinical manifestations of functional dyspepsia and patients quality of life |
| topic | functional dyspepsia lactobacillus delbrueckii subsp. bulgaricus gastrointestinal symptom rating scale quality of life |
| url | https://gastro.zaslavsky.com.ua/index.php/journal/article/view/634 |
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