Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response
IntroductionThe innate immune response is an important first checkpoint in the evolution of an infection. Although adaptive immunity is generally considered the immune component that retains antigenic memory, innate immune responses can also be affected by previous stimulations. This study evaluated...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1513717/full |
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| author | Hend Jarras Isalie Blais Benjamin Goyer Wilfried W. Bazié Wilfried W. Bazié Henintsoa Rabezanahary Mathieu Thériault Kim Santerre Marc-André Langlois Jean-François Masson Joelle N. Pelletier Joelle N. Pelletier Nicholas Brousseau Nicholas Brousseau Denis Boudreau Sylvie Trottier Sylvie Trottier Mariana Baz Mariana Baz Caroline Gilbert Caroline Gilbert |
| author_facet | Hend Jarras Isalie Blais Benjamin Goyer Wilfried W. Bazié Wilfried W. Bazié Henintsoa Rabezanahary Mathieu Thériault Kim Santerre Marc-André Langlois Jean-François Masson Joelle N. Pelletier Joelle N. Pelletier Nicholas Brousseau Nicholas Brousseau Denis Boudreau Sylvie Trottier Sylvie Trottier Mariana Baz Mariana Baz Caroline Gilbert Caroline Gilbert |
| author_sort | Hend Jarras |
| collection | DOAJ |
| description | IntroductionThe innate immune response is an important first checkpoint in the evolution of an infection. Although adaptive immunity is generally considered the immune component that retains antigenic memory, innate immune responses can also be affected by previous stimulations. This study evaluated the impact of vaccination on innate cell activation by TLR7/8 agonist R848, as well as seasonal variations.MethodsTo this end, blood samples from a cohort of 304 food and retail workers from the Quebec City region were collected during three visits at 12-week intervals. Peripheral blood mononuclear cells and polymorphonuclear neutrophils were isolated during the first and third visits and were stimulated with R848 to assess the innate immune response.ResultsOur results show that IL-8 production after stimulation decreased after vaccination. In addition, the IL-8 response was significantly different depending on the season when the visit occurred, for both COVID-19 vaccinated and unvaccinated individuals.DiscussionThis study highlights that innate immune responses can be affected by SARS-CoV-2 vaccination and fluctuate seasonally. |
| format | Article |
| id | doaj-art-a1517cf039c14837aea8159c8793ec5d |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-a1517cf039c14837aea8159c8793ec5d2025-01-14T08:03:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15137171513717Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory responseHend Jarras0Isalie Blais1Benjamin Goyer2Wilfried W. Bazié3Wilfried W. Bazié4Henintsoa Rabezanahary5Mathieu Thériault6Kim Santerre7Marc-André Langlois8Jean-François Masson9Joelle N. Pelletier10Joelle N. Pelletier11Nicholas Brousseau12Nicholas Brousseau13Denis Boudreau14Sylvie Trottier15Sylvie Trottier16Mariana Baz17Mariana Baz18Caroline Gilbert19Caroline Gilbert20Axe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, CanadaAxe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, CanadaAxe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, CanadaAxe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, CanadaProgramme de Recherche sur les Maladies Infectieuses, Centre Muraz, Institut National de Santé Publique, Bobo-Dioulasso, Houet, Burkina FasoAxe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, CanadaAxe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, CanadaAxe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, CanadaDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, CanadaDepartment of Chemistry, Institut Courtois, Quebec Center for Advanced Materials, Regroupement québécois sur les matériaux de pointe, and Centre Interdisciplinaire de Recherche sur le Cerveau et l’Apprentissage, Université de Montréal, Montreal, QC, CanadaDepartment of Chemistry, Department of Biochemistry, Université de Montréal, Montreal, QC, CanadaPROTEO — The Québec Network for Research on Protein Function, Engineering, and Applications, Quebec City, QC, CanadaAxe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, CanadaBiological Risks Department, Institut national de santé publique du Québec, Quebec City, QC, CanadaDépartement de Chimie et Center for Optics, Photonics and Lasers (COPL), Université Laval, Quebec City, QC, CanadaAxe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, CanadaDépartement de Microbiologie-Infectiologie et d’Immunologie, Faculté de Médecine, Université Laval, Quebec City, QC, CanadaAxe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, CanadaDépartement de Microbiologie-Infectiologie et d’Immunologie, Faculté de Médecine, Université Laval, Quebec City, QC, CanadaAxe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, CanadaDépartement de Microbiologie-Infectiologie et d’Immunologie, Faculté de Médecine, Université Laval, Quebec City, QC, CanadaIntroductionThe innate immune response is an important first checkpoint in the evolution of an infection. Although adaptive immunity is generally considered the immune component that retains antigenic memory, innate immune responses can also be affected by previous stimulations. This study evaluated the impact of vaccination on innate cell activation by TLR7/8 agonist R848, as well as seasonal variations.MethodsTo this end, blood samples from a cohort of 304 food and retail workers from the Quebec City region were collected during three visits at 12-week intervals. Peripheral blood mononuclear cells and polymorphonuclear neutrophils were isolated during the first and third visits and were stimulated with R848 to assess the innate immune response.ResultsOur results show that IL-8 production after stimulation decreased after vaccination. In addition, the IL-8 response was significantly different depending on the season when the visit occurred, for both COVID-19 vaccinated and unvaccinated individuals.DiscussionThis study highlights that innate immune responses can be affected by SARS-CoV-2 vaccination and fluctuate seasonally.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1513717/fullSARS-CoV-2vaccineseasoninnate immunityperipheral blood mononuclear cellspolymorphonuclear neutrophils |
| spellingShingle | Hend Jarras Isalie Blais Benjamin Goyer Wilfried W. Bazié Wilfried W. Bazié Henintsoa Rabezanahary Mathieu Thériault Kim Santerre Marc-André Langlois Jean-François Masson Joelle N. Pelletier Joelle N. Pelletier Nicholas Brousseau Nicholas Brousseau Denis Boudreau Sylvie Trottier Sylvie Trottier Mariana Baz Mariana Baz Caroline Gilbert Caroline Gilbert Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response Frontiers in Immunology SARS-CoV-2 vaccine season innate immunity peripheral blood mononuclear cells polymorphonuclear neutrophils |
| title | Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response |
| title_full | Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response |
| title_fullStr | Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response |
| title_full_unstemmed | Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response |
| title_short | Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response |
| title_sort | impact of sars cov 2 vaccination and of seasonal variations on the innate immune inflammatory response |
| topic | SARS-CoV-2 vaccine season innate immunity peripheral blood mononuclear cells polymorphonuclear neutrophils |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1513717/full |
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