HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition

HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition

Abstract Atherosclerosis (AS), driven by vascular endothelial dysfunction and poses a global health threat. This study compared the therapeutic effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on vascular endothelial function in early-stage AS mice...

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Bibliographic Details
Main Authors: Guochun Liu, Binyi Zhao, Qinglong Chen, Xiang Li, Xuejiao Zhu, Maowei Duan, Mengdie Zhang, Zhuohan Liu, Xuan Wen, Jia Guo, Man Zheng, Ruiyu Wang, Minghao Luo
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Atherosclerosis
Exercise
Endothelial dysfunction
Pyroptosis
Online Access:https://doi.org/10.1038/s41598-025-05206-7
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