Comprehensive analysis of targetable mutations and tumor microenvironment in urachal cancer
Abstract Urachal cancer, a rare malignancy, generally presents in the clinical setting with advanced stages of disease. Systemic treatment with chemotherapy is generally utilized in this setting. However, there remains a paucity of data on the effectiveness of immune checkpoint inhibitors or targete...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-024-00795-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544991196839936 |
|---|---|
| author | David J. Benjamin Tolulope T. Adeyelu Andrew Elliott Sourat Darabi Thomas Lee Rana R. McKay Matthew J. Oberley Arash Rezazadeh Kalebasty |
| author_facet | David J. Benjamin Tolulope T. Adeyelu Andrew Elliott Sourat Darabi Thomas Lee Rana R. McKay Matthew J. Oberley Arash Rezazadeh Kalebasty |
| author_sort | David J. Benjamin |
| collection | DOAJ |
| description | Abstract Urachal cancer, a rare malignancy, generally presents in the clinical setting with advanced stages of disease. Systemic treatment with chemotherapy is generally utilized in this setting. However, there remains a paucity of data on the effectiveness of immune checkpoint inhibitors or targeted therapies for urachal cancer. We analyzed the genomic profile of urachal cancer in order to identify potentially targetable mutations and evaluate the tumor microenvironment. 42 urachal samples were retrospectively analyzed. Our results showed that TP53, GNAS and KRAS mutations were common in urachal cancer with increased prevalence of TP53 mutation in urachal cohorts without MAPK-alterations. The tumor microenvironment demonstrated increased NK cells in MAPK-altered urachal cancer. Finally, we show that urachal cancer shares genomic and transcriptomic similarity with colorectal cancer compared to bladder cancer. This study provides new insights into the molecular profiles of urachal tumor samples and possibility of association with colorectal cancer that might guide future clinical trial design. |
| format | Article |
| id | doaj-art-a12f9e916b6d4cac8b800def7ce5872a |
| institution | Kabale University |
| issn | 2397-768X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Precision Oncology |
| spelling | doaj-art-a12f9e916b6d4cac8b800def7ce5872a2025-01-12T12:06:25ZengNature Portfolionpj Precision Oncology2397-768X2025-01-01911810.1038/s41698-024-00795-4Comprehensive analysis of targetable mutations and tumor microenvironment in urachal cancerDavid J. Benjamin0Tolulope T. Adeyelu1Andrew Elliott2Sourat Darabi3Thomas Lee4Rana R. McKay5Matthew J. Oberley6Arash Rezazadeh Kalebasty7Hoag Family Cancer InstituteCaris Life SciencesCaris Life SciencesHoag Family Cancer InstituteHoag Memorial Hospital PresbyterianUniversity of California, San Diego HealthCaris Life SciencesUniversity of California, IrvineAbstract Urachal cancer, a rare malignancy, generally presents in the clinical setting with advanced stages of disease. Systemic treatment with chemotherapy is generally utilized in this setting. However, there remains a paucity of data on the effectiveness of immune checkpoint inhibitors or targeted therapies for urachal cancer. We analyzed the genomic profile of urachal cancer in order to identify potentially targetable mutations and evaluate the tumor microenvironment. 42 urachal samples were retrospectively analyzed. Our results showed that TP53, GNAS and KRAS mutations were common in urachal cancer with increased prevalence of TP53 mutation in urachal cohorts without MAPK-alterations. The tumor microenvironment demonstrated increased NK cells in MAPK-altered urachal cancer. Finally, we show that urachal cancer shares genomic and transcriptomic similarity with colorectal cancer compared to bladder cancer. This study provides new insights into the molecular profiles of urachal tumor samples and possibility of association with colorectal cancer that might guide future clinical trial design.https://doi.org/10.1038/s41698-024-00795-4 |
| spellingShingle | David J. Benjamin Tolulope T. Adeyelu Andrew Elliott Sourat Darabi Thomas Lee Rana R. McKay Matthew J. Oberley Arash Rezazadeh Kalebasty Comprehensive analysis of targetable mutations and tumor microenvironment in urachal cancer npj Precision Oncology |
| title | Comprehensive analysis of targetable mutations and tumor microenvironment in urachal cancer |
| title_full | Comprehensive analysis of targetable mutations and tumor microenvironment in urachal cancer |
| title_fullStr | Comprehensive analysis of targetable mutations and tumor microenvironment in urachal cancer |
| title_full_unstemmed | Comprehensive analysis of targetable mutations and tumor microenvironment in urachal cancer |
| title_short | Comprehensive analysis of targetable mutations and tumor microenvironment in urachal cancer |
| title_sort | comprehensive analysis of targetable mutations and tumor microenvironment in urachal cancer |
| url | https://doi.org/10.1038/s41698-024-00795-4 |
| work_keys_str_mv | AT davidjbenjamin comprehensiveanalysisoftargetablemutationsandtumormicroenvironmentinurachalcancer AT tolulopetadeyelu comprehensiveanalysisoftargetablemutationsandtumormicroenvironmentinurachalcancer AT andrewelliott comprehensiveanalysisoftargetablemutationsandtumormicroenvironmentinurachalcancer AT souratdarabi comprehensiveanalysisoftargetablemutationsandtumormicroenvironmentinurachalcancer AT thomaslee comprehensiveanalysisoftargetablemutationsandtumormicroenvironmentinurachalcancer AT ranarmckay comprehensiveanalysisoftargetablemutationsandtumormicroenvironmentinurachalcancer AT matthewjoberley comprehensiveanalysisoftargetablemutationsandtumormicroenvironmentinurachalcancer AT arashrezazadehkalebasty comprehensiveanalysisoftargetablemutationsandtumormicroenvironmentinurachalcancer |