Sleep quality and the integrity of ascending reticular activating system – A multimodal MRI study
Sleep is crucial for maintaining brain homeostasis and individuals with insufficient sleep are prone to more pronounced brain atrophy as compared to sufficiently sleeping peers. Moreover, sleep quality deteriorates with ageing and ageing is also associated with cerebral structural and functional cha...
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| Language: | English |
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Elsevier
2024-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024162238 |
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| author | Viktória Kokošová Lubomír Vojtíšek Marek Baláž Silvia Mangia Shalom Michaeli Pavel Filip |
| author_facet | Viktória Kokošová Lubomír Vojtíšek Marek Baláž Silvia Mangia Shalom Michaeli Pavel Filip |
| author_sort | Viktória Kokošová |
| collection | DOAJ |
| description | Sleep is crucial for maintaining brain homeostasis and individuals with insufficient sleep are prone to more pronounced brain atrophy as compared to sufficiently sleeping peers. Moreover, sleep quality deteriorates with ageing and ageing is also associated with cerebral structural and functional changes, pointing to their mutual bidirectional interrelationship. This study aimed at determining whether sleep quality and age, separately, affect brain integrity and subsequently, whether sleep significantly modulates the effect of age on brain structural and functional integrity. 113 healthy volunteers underwent a multi-modal MRI imaging to extract information about the microstructure and function of major nodes of the ascending reticular activating system. Sleep quality was assessed by self-administered Pittsburgh's sleep quality index (PSQI) questionnaire. Subject were divided into good (global PSQI score <5) and poor (global PSQI score ≥5) sleep quality group. Whereas only borderline correlations were found between sleep quality and MRI metrics, age exhibited widespread correlations with both functional and microstructural MRI metrics. The latter effect was significantly modulated by sleep quality in ascending reticular activating system, hypothalamus, thalamus and also hippocampus in MRI metrics associated with iron load, cellularity and connectivity, mainly in the subgroup with poor sleep quality. Ergo, our results indicate sleep quality as a substantial contributor to both microstructural and functional brain changes in ageing and call for further research in this emerging topic. |
| format | Article |
| id | doaj-art-a12634a2b4c74aee8891c1746b92abdb |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-a12634a2b4c74aee8891c1746b92abdb2024-11-30T07:12:03ZengElsevierHeliyon2405-84402024-11-011022e40192Sleep quality and the integrity of ascending reticular activating system – A multimodal MRI studyViktória Kokošová0Lubomír Vojtíšek1Marek Baláž2Silvia Mangia3Shalom Michaeli4Pavel Filip5First Department of Neurology, Faculty of Medicine, Masaryk University and University Hospital of St. Anne, Brno, Czech Republic; Department of Neurology, Faculty of Medicine, Masaryk University and University Hospital Brno, Brno, Czech RepublicCentral European Institute of Technology (CEITEC) Masaryk University, Neuroscience Centre, Brno, Czech RepublicFirst Department of Neurology, Faculty of Medicine, Masaryk University and University Hospital of St. Anne, Brno, Czech RepublicCenter for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USACenter for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USACenter for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA; Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic; Department of Cybernetics, Czech Technical University in Prague, Prague, Czech Republic; Corresponding author. Neurologická klinika 1. LF a VFN, Kateřinská 468, 120 00, Prague, Czech Republic.Sleep is crucial for maintaining brain homeostasis and individuals with insufficient sleep are prone to more pronounced brain atrophy as compared to sufficiently sleeping peers. Moreover, sleep quality deteriorates with ageing and ageing is also associated with cerebral structural and functional changes, pointing to their mutual bidirectional interrelationship. This study aimed at determining whether sleep quality and age, separately, affect brain integrity and subsequently, whether sleep significantly modulates the effect of age on brain structural and functional integrity. 113 healthy volunteers underwent a multi-modal MRI imaging to extract information about the microstructure and function of major nodes of the ascending reticular activating system. Sleep quality was assessed by self-administered Pittsburgh's sleep quality index (PSQI) questionnaire. Subject were divided into good (global PSQI score <5) and poor (global PSQI score ≥5) sleep quality group. Whereas only borderline correlations were found between sleep quality and MRI metrics, age exhibited widespread correlations with both functional and microstructural MRI metrics. The latter effect was significantly modulated by sleep quality in ascending reticular activating system, hypothalamus, thalamus and also hippocampus in MRI metrics associated with iron load, cellularity and connectivity, mainly in the subgroup with poor sleep quality. Ergo, our results indicate sleep quality as a substantial contributor to both microstructural and functional brain changes in ageing and call for further research in this emerging topic.http://www.sciencedirect.com/science/article/pii/S2405844024162238Sleep qualityBrain ageingMultimodal MRIRelaxometryDiffusion weighted imaging |
| spellingShingle | Viktória Kokošová Lubomír Vojtíšek Marek Baláž Silvia Mangia Shalom Michaeli Pavel Filip Sleep quality and the integrity of ascending reticular activating system – A multimodal MRI study Heliyon Sleep quality Brain ageing Multimodal MRI Relaxometry Diffusion weighted imaging |
| title | Sleep quality and the integrity of ascending reticular activating system – A multimodal MRI study |
| title_full | Sleep quality and the integrity of ascending reticular activating system – A multimodal MRI study |
| title_fullStr | Sleep quality and the integrity of ascending reticular activating system – A multimodal MRI study |
| title_full_unstemmed | Sleep quality and the integrity of ascending reticular activating system – A multimodal MRI study |
| title_short | Sleep quality and the integrity of ascending reticular activating system – A multimodal MRI study |
| title_sort | sleep quality and the integrity of ascending reticular activating system a multimodal mri study |
| topic | Sleep quality Brain ageing Multimodal MRI Relaxometry Diffusion weighted imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024162238 |
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