Sex-specific role of epigenetic modification of a leptin upstream enhancer in adipose tissue

Sex-specific role of epigenetic modification of a leptin upstream enhancer in adipose tissue

Abstract Objective Maternal hormonal status can have long-term effects on offspring metabolic health and is likely regulated via epigenetic mechanisms. We elucidated the effects of maternal thyroid hormones on the epigenetic regulation of leptin (Lep) transcription in adipose tissue (AT) and subsequ...

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Main Authors: Luise Müller, Rebecca Oelkrug, Jens Mittag, Anne Hoffmann, Adhideb Ghosh, Falko Noé, Christian Wolfrum, Esther Guiu Jurado, Nora Klöting, Arne Dietrich, Matthias Blüher, Peter Kovacs, Kerstin Krause, Maria Keller
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Clinical Epigenetics
Subjects:
Maternal thyroid hormones
Body fat
Leptin upstream enhancer
DNA methylation
Sex specific
Adipose tissue
Online Access:https://doi.org/10.1186/s13148-025-01830-2
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