Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors

Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors

ABSTRACT This study emphasizes the critical importance of closely monitoring and controlling the sialic acid content in therapeutic glycoproteins, including EPO, interferon‐γ, Orencia, Enbrel, and others, as the level of sialylation directly impacts their pharmacokinetics (PK), immunogenicity, poten...

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Bibliographic Details
Main Authors: Letha Chemmalil, Tanmay Kulkarni, Mathura Raman, Priya Singh, Yueming Qian, Chris Chumsae, Kyle McHugh, Zhuangrong Huang, Eric Hodgman, Michael C. Borys, Julia Ding, Gloria Li, Anthony Leone
Format: Article
Language:English
Published: Wiley-VCH 2025-01-01
Series:Engineering in Life Sciences
Subjects:
µSIA
continuous bioprocessing
FIA labs
monoclonal antibody (mAb)
process analytical technology (PAT)
quality by design (QbD)
Online Access:https://doi.org/10.1002/elsc.202400031
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