Application of biomarkers in the assessment and treatment of cancer-related fatigue
Abstract Cancer-related fatigue (CRF) is a common side effect experienced by cancer patients and disease-free survivors, significantly impacting their quality of life. This review summarizes the application of biomarkers in assessment and treatment of CRF, while exploring its biological basis throug...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Holistic Integrative Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s44178-025-00167-3 |
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| _version_ | 1849334474274242560 |
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| author | Hui-Hui Hu Huan Zhao Yong-Jing Ren Sai-Qi Wang Zhe-Sheng Chen Hong Guo Yu-Hua He Xiao-Hui Gao Xiaobing Chen |
| author_facet | Hui-Hui Hu Huan Zhao Yong-Jing Ren Sai-Qi Wang Zhe-Sheng Chen Hong Guo Yu-Hua He Xiao-Hui Gao Xiaobing Chen |
| author_sort | Hui-Hui Hu |
| collection | DOAJ |
| description | Abstract Cancer-related fatigue (CRF) is a common side effect experienced by cancer patients and disease-free survivors, significantly impacting their quality of life. This review summarizes the application of biomarkers in assessment and treatment of CRF, while exploring its biological basis through inflammatory pathways, neuroendocrine responses, metabolic disorders, mitochondrial dysfunction, and oxidative stress. Furthermore, the paper discusses the potential and value of biomarkers in CRF management, including therapeutic approaches such as psychostimulants, corticosteroids, nutritional supplements, and exercise interventions. The development of biomarkers offers a new perspective for the early identification, diagnosis, and treatment of CRF. |
| format | Article |
| id | doaj-art-a0fe4abd3d7148b68cc3d01933e707d2 |
| institution | Kabale University |
| issn | 2731-4529 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Holistic Integrative Oncology |
| spelling | doaj-art-a0fe4abd3d7148b68cc3d01933e707d22025-08-20T03:45:33ZengSpringerHolistic Integrative Oncology2731-45292025-06-014112010.1007/s44178-025-00167-3Application of biomarkers in the assessment and treatment of cancer-related fatigueHui-Hui Hu0Huan Zhao1Yong-Jing Ren2Sai-Qi Wang3Zhe-Sheng Chen4Hong Guo5Yu-Hua He6Xiao-Hui Gao7Xiaobing Chen8Department of Oncology, Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer & Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Oncology, Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer & Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Oncology, Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer & Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Oncology, Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer & Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Henan University of Science and TechnologyDepartment of Oncology, The First Affiliated Hospital of Henan University of Science and TechnologyDepartment of Oncology, The First Affiliated Hospital of Henan University of Science and TechnologyDepartment of Oncology, Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer & Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalAbstract Cancer-related fatigue (CRF) is a common side effect experienced by cancer patients and disease-free survivors, significantly impacting their quality of life. This review summarizes the application of biomarkers in assessment and treatment of CRF, while exploring its biological basis through inflammatory pathways, neuroendocrine responses, metabolic disorders, mitochondrial dysfunction, and oxidative stress. Furthermore, the paper discusses the potential and value of biomarkers in CRF management, including therapeutic approaches such as psychostimulants, corticosteroids, nutritional supplements, and exercise interventions. The development of biomarkers offers a new perspective for the early identification, diagnosis, and treatment of CRF.https://doi.org/10.1007/s44178-025-00167-3Cancer-related fatigueBiomarkersExerciseTreatmentIndividualizationInflammatory reaction |
| spellingShingle | Hui-Hui Hu Huan Zhao Yong-Jing Ren Sai-Qi Wang Zhe-Sheng Chen Hong Guo Yu-Hua He Xiao-Hui Gao Xiaobing Chen Application of biomarkers in the assessment and treatment of cancer-related fatigue Holistic Integrative Oncology Cancer-related fatigue Biomarkers Exercise Treatment Individualization Inflammatory reaction |
| title | Application of biomarkers in the assessment and treatment of cancer-related fatigue |
| title_full | Application of biomarkers in the assessment and treatment of cancer-related fatigue |
| title_fullStr | Application of biomarkers in the assessment and treatment of cancer-related fatigue |
| title_full_unstemmed | Application of biomarkers in the assessment and treatment of cancer-related fatigue |
| title_short | Application of biomarkers in the assessment and treatment of cancer-related fatigue |
| title_sort | application of biomarkers in the assessment and treatment of cancer related fatigue |
| topic | Cancer-related fatigue Biomarkers Exercise Treatment Individualization Inflammatory reaction |
| url | https://doi.org/10.1007/s44178-025-00167-3 |
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