Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry
Background: Little is known about the extent of impairments in work and activities of daily life (ADL) in patients with psoriasis, and the influence of contextual factors such as disease-related characteristics and treatment. Therefore, this study aimed to assess these impairments in patients with p...
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2024.2304025 |
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| author | Tamara W. van Hal Juul M. P. A. van den Reek Mark H. Wenink Marisol E. Otero Paul M. Ossenkoppele Marcellus D. Njoo Annet Oostveen Bas Peters Milan Tjioe Else N. Kop John E. M. Körver Sharon R. P. Dodemont Marloes M. Kleinpenning Maartje A. M. Berends Wendelien R. Veldkamp Martijn B. A. van Doorn Johannes M. Mommers Robert-Jan Lindhout Astrid L. A. Kuijpers Paula P. van Lümig C. (Els) J. de Jonge Ron A. Tupker Judith Hendricksen Romy R. Keijsers Frank H. J. van den Hoogen Johanna E. Vriezekolk Elke M. G. J. de Jong |
| author_facet | Tamara W. van Hal Juul M. P. A. van den Reek Mark H. Wenink Marisol E. Otero Paul M. Ossenkoppele Marcellus D. Njoo Annet Oostveen Bas Peters Milan Tjioe Else N. Kop John E. M. Körver Sharon R. P. Dodemont Marloes M. Kleinpenning Maartje A. M. Berends Wendelien R. Veldkamp Martijn B. A. van Doorn Johannes M. Mommers Robert-Jan Lindhout Astrid L. A. Kuijpers Paula P. van Lümig C. (Els) J. de Jonge Ron A. Tupker Judith Hendricksen Romy R. Keijsers Frank H. J. van den Hoogen Johanna E. Vriezekolk Elke M. G. J. de Jong |
| author_sort | Tamara W. van Hal |
| collection | DOAJ |
| description | Background: Little is known about the extent of impairments in work and activities of daily life (ADL) in patients with psoriasis, and the influence of contextual factors such as disease-related characteristics and treatment. Therefore, this study aimed to assess these impairments in patients with psoriasis who started using biologicals/small molecule inhibitors.Methods: Using data from the prospective BioCAPTURE registry, we collected patient, disease, and treatment parameters, as well as work/ADL impairments at baseline, 6 and 12 months. Changes in impairment parameters and correlations between impairment and patient/disease characteristics were assessed using generalized estimating equations.Results: We included 194 patients in our analysis. After biological initiation, disease activity decreased significantly (PASI 11.2 at baseline versus 3.9 at 12 months, p < 0.001). Work-for-pay in this cohort was lower than in the Dutch general population (53% versus 67%, p = 0.01). In patients who had work-for-pay, presenteeism improved over time (5% at baseline versus 0% at 12 months, p = 0.04). Up to half of the patients reported impairments in ADL, which did not change over time. Associations between impairments and contextual factors varied, but all impairments were associated with worse mental/physical general functioning.Conclusion: Patients with psoriasis using biologicals are less likely to have work-for-pay. Treatment improves the work productivity of employed patients, but we were unable to detect changes in ADL performance. |
| format | Article |
| id | doaj-art-a0ecbd2dbd2848a58e15cb47119ba98d |
| institution | Kabale University |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-a0ecbd2dbd2848a58e15cb47119ba98d2024-12-16T22:53:48ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532024-12-0135110.1080/09546634.2024.2304025Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registryTamara W. van Hal0Juul M. P. A. van den Reek1Mark H. Wenink2Marisol E. Otero3Paul M. Ossenkoppele4Marcellus D. Njoo5Annet Oostveen6Bas Peters7Milan Tjioe8Else N. Kop9John E. M. Körver10Sharon R. P. Dodemont11Marloes M. Kleinpenning12Maartje A. M. Berends13Wendelien R. Veldkamp14Martijn B. A. van Doorn15Johannes M. Mommers16Robert-Jan Lindhout17Astrid L. A. Kuijpers18Paula P. van Lümig19C. (Els) J. de Jonge20Ron A. Tupker21Judith Hendricksen22Romy R. Keijsers23Frank H. J. van den Hoogen24Johanna E. Vriezekolk25Elke M. G. J. de Jong26Department of Rheumatology, Sint Maartenskliniek, Nijmegen, the NetherlandsRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the NetherlandsDepartment of Rheumatology, Sint Maartenskliniek, Nijmegen, the NetherlandsDepartment of Dermatology, Radboud University Medical Center, Nijmegen, the NetherlandsDepartment of Dermatology, ZiekenhuisGroep Twente, Almelo/Hengelo, the NetherlandsDepartment of Dermatology, ZiekenhuisGroep Twente, Almelo/Hengelo, the NetherlandsDepartment of Dermatology, Gelre Ziekenhuizen, Apeldoorn, the NetherlandsDepartment of Dermatology, Ziekenhuis Rijnstate, Arnhem, the NetherlandsDepartment of Dermatology/DermaTeam, Bravis Ziekenhuis, Bergen op Zoom, the NetherlandsDepartment of Dermatology, Bernhoven Ziekenhuis, Uden, the NetherlandsDepartment of Dermatology, Amphia Ziekenhuis, Breda, the NetherlandsDepartment of Dermatology, Catharina Ziekenhuis, Eindhoven, the NetherlandsDepartment of Dermatology, Canisius-Wilhelmina Ziekenhuis, Nijmegen, the NetherlandsDepartment of Dermatology, Slingeland Ziekenhuis, Doetinchem, the NetherlandsDepartment of Dermatology, Ziekenhuis Gelderse Vallei, Ede, the NetherlandsDepartment of Dermatology, ErasmusMC, Rotterdam, the NetherlandsDepartment of Dermatology, St. Anna Ziekenhuis, Geldrop, the NetherlandsDepartment of Dermatology, Jeroen Bosch Ziekenhuis, ‘s Hertogenbosch, the NetherlandsDepartment of Dermatology, Maxima Medisch Centrum, Eindhoven, the NetherlandsDepartment of Dermatology, Maastricht UMC+, Maastricht, the NetherlandsDepartment of Dermatology, UMC Utrecht, Utrecht, the NetherlandsDepartment of Dermatology, Sint Antoniusziekenhuis, Nieuwegein, the NetherlandsDepartment of Dermatology, Streekziekenhuis Koningin Beatrix, Winterswijk, the NetherlandsDepartment of Dermatology, Zuyderland Medisch Centrum, Sittard-Geleen, the NetherlandsFaculty of Medical Sciences, Radboud University, Nijmegen, the NetherlandsDepartment of Rheumatology, Sint Maartenskliniek, Nijmegen, the NetherlandsRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the NetherlandsBackground: Little is known about the extent of impairments in work and activities of daily life (ADL) in patients with psoriasis, and the influence of contextual factors such as disease-related characteristics and treatment. Therefore, this study aimed to assess these impairments in patients with psoriasis who started using biologicals/small molecule inhibitors.Methods: Using data from the prospective BioCAPTURE registry, we collected patient, disease, and treatment parameters, as well as work/ADL impairments at baseline, 6 and 12 months. Changes in impairment parameters and correlations between impairment and patient/disease characteristics were assessed using generalized estimating equations.Results: We included 194 patients in our analysis. After biological initiation, disease activity decreased significantly (PASI 11.2 at baseline versus 3.9 at 12 months, p < 0.001). Work-for-pay in this cohort was lower than in the Dutch general population (53% versus 67%, p = 0.01). In patients who had work-for-pay, presenteeism improved over time (5% at baseline versus 0% at 12 months, p = 0.04). Up to half of the patients reported impairments in ADL, which did not change over time. Associations between impairments and contextual factors varied, but all impairments were associated with worse mental/physical general functioning.Conclusion: Patients with psoriasis using biologicals are less likely to have work-for-pay. Treatment improves the work productivity of employed patients, but we were unable to detect changes in ADL performance.https://www.tandfonline.com/doi/10.1080/09546634.2024.2304025Psoriasisworkactivities of daily living |
| spellingShingle | Tamara W. van Hal Juul M. P. A. van den Reek Mark H. Wenink Marisol E. Otero Paul M. Ossenkoppele Marcellus D. Njoo Annet Oostveen Bas Peters Milan Tjioe Else N. Kop John E. M. Körver Sharon R. P. Dodemont Marloes M. Kleinpenning Maartje A. M. Berends Wendelien R. Veldkamp Martijn B. A. van Doorn Johannes M. Mommers Robert-Jan Lindhout Astrid L. A. Kuijpers Paula P. van Lümig C. (Els) J. de Jonge Ron A. Tupker Judith Hendricksen Romy R. Keijsers Frank H. J. van den Hoogen Johanna E. Vriezekolk Elke M. G. J. de Jong Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry Journal of Dermatological Treatment Psoriasis work activities of daily living |
| title | Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry |
| title_full | Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry |
| title_fullStr | Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry |
| title_full_unstemmed | Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry |
| title_short | Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry |
| title_sort | impairment in work and activities of daily life in patients with psoriasis results of the prospective biocapture registry |
| topic | Psoriasis work activities of daily living |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2024.2304025 |
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