Sedated and unsedated gastroscopy has no influence on the outcomes of patients with gastric cancer: a retrospective study
Abstract Background Different anesthetic drugs and techniques may affect survival outcomes for gastric cancer (GC) after surgery. In this study, we investigated the association between sedated and unsedated gastroscopy on survival outcomes in patients with GC after surgery. Methods This was a retros...
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BMC
2025-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-13413-0 |
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| author | Chengke Yin Yiwu Sun Jie Liang Xin Sui Zhaoyi He Ailing Song Wenjia Xu Lei Zhang Yufei Sun Jingshun Zhao Fei Han |
| author_facet | Chengke Yin Yiwu Sun Jie Liang Xin Sui Zhaoyi He Ailing Song Wenjia Xu Lei Zhang Yufei Sun Jingshun Zhao Fei Han |
| author_sort | Chengke Yin |
| collection | DOAJ |
| description | Abstract Background Different anesthetic drugs and techniques may affect survival outcomes for gastric cancer (GC) after surgery. In this study, we investigated the association between sedated and unsedated gastroscopy on survival outcomes in patients with GC after surgery. Methods This was a retrospective study of patients who were diagnosed with GC by gastroscopy and underwent gastrectomy from January 2013 to December 2017. They were grouped based on the examination modality: propofol-based sedated gastroscopy or unsedated gastroscopy. Propensity score matching (PSM) was used to balance the baseline variables. Survival outcomes and distant metastases were compared between these two groups. Results Finally, 673 patients were enrolled, 160 in the sedated gastroscopy group and 513 in the unsedated gastroscopy group. After PSM, there were 160 patients in each group. There was no significant difference in overall survival outcomes in the sedated gastroscopy group compared to the unsedated gastroscopy group before PSM (HR = 0.761, 95% CI: 0.531–1.091, P = 0.139) or after PSM (HR = 0.874, 95% CI: 0.564–1.355, P = 0.547). There was no significant difference in the incidence of distant metastases between the two groups before PSM (16.9% vs. 20.7%, P = 0.294) or after PSM (16.9% vs. 23.8%, P = 0.126). To confirm that our patients behaved similarly to other studies, we performed a multivariate analysis and the results showed that sex, pathological TNM stage, Borrmann type, adjuvant treatment, and surgical resection range were all independent factors affecting survival outcomes in our patients. Conclusion Our results showed no significant difference in the effects of sedated gastroscopy vs. unsedated gastroscopy on survival outcomes or distant metastases of patients after gastrectomy for GC. |
| format | Article |
| id | doaj-art-a0d51f053cf340f7a2d6144ccc6225f1 |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-a0d51f053cf340f7a2d6144ccc6225f12025-01-12T12:27:29ZengBMCBMC Cancer1471-24072025-01-0125111210.1186/s12885-024-13413-0Sedated and unsedated gastroscopy has no influence on the outcomes of patients with gastric cancer: a retrospective studyChengke Yin0Yiwu Sun1Jie Liang2Xin Sui3Zhaoyi He4Ailing Song5Wenjia Xu6Lei Zhang7Yufei Sun8Jingshun Zhao9Fei Han10Department of Anesthesiology, Harbin Medical University Cancer HospitalDepartment of Anesthesiology, Dazhou Central HospitalDepartment of Anesthesiology, Harbin Medical University Cancer HospitalDepartment of Anesthesiology, Harbin Medical University Cancer HospitalDepartment of Anesthesiology, Harbin Medical University Cancer HospitalDepartment of Anesthesiology, Shanghai Jiaotong University First People’s HospitalDepartment of Anesthesiology, Harbin Medical University Cancer HospitalDepartment of Anesthesiology, Harbin Medical University Cancer HospitalDepartment of Anesthesiology, Harbin Medical University Cancer HospitalDepartment of Anesthesiology, Harbin Medical University Cancer HospitalDepartment of Anesthesiology, Harbin Medical University Cancer HospitalAbstract Background Different anesthetic drugs and techniques may affect survival outcomes for gastric cancer (GC) after surgery. In this study, we investigated the association between sedated and unsedated gastroscopy on survival outcomes in patients with GC after surgery. Methods This was a retrospective study of patients who were diagnosed with GC by gastroscopy and underwent gastrectomy from January 2013 to December 2017. They were grouped based on the examination modality: propofol-based sedated gastroscopy or unsedated gastroscopy. Propensity score matching (PSM) was used to balance the baseline variables. Survival outcomes and distant metastases were compared between these two groups. Results Finally, 673 patients were enrolled, 160 in the sedated gastroscopy group and 513 in the unsedated gastroscopy group. After PSM, there were 160 patients in each group. There was no significant difference in overall survival outcomes in the sedated gastroscopy group compared to the unsedated gastroscopy group before PSM (HR = 0.761, 95% CI: 0.531–1.091, P = 0.139) or after PSM (HR = 0.874, 95% CI: 0.564–1.355, P = 0.547). There was no significant difference in the incidence of distant metastases between the two groups before PSM (16.9% vs. 20.7%, P = 0.294) or after PSM (16.9% vs. 23.8%, P = 0.126). To confirm that our patients behaved similarly to other studies, we performed a multivariate analysis and the results showed that sex, pathological TNM stage, Borrmann type, adjuvant treatment, and surgical resection range were all independent factors affecting survival outcomes in our patients. Conclusion Our results showed no significant difference in the effects of sedated gastroscopy vs. unsedated gastroscopy on survival outcomes or distant metastases of patients after gastrectomy for GC.https://doi.org/10.1186/s12885-024-13413-0AnesthesiaGastric cancerSedated gastroscopyUnsedated gastroscopyComfort of gastroscopy |
| spellingShingle | Chengke Yin Yiwu Sun Jie Liang Xin Sui Zhaoyi He Ailing Song Wenjia Xu Lei Zhang Yufei Sun Jingshun Zhao Fei Han Sedated and unsedated gastroscopy has no influence on the outcomes of patients with gastric cancer: a retrospective study BMC Cancer Anesthesia Gastric cancer Sedated gastroscopy Unsedated gastroscopy Comfort of gastroscopy |
| title | Sedated and unsedated gastroscopy has no influence on the outcomes of patients with gastric cancer: a retrospective study |
| title_full | Sedated and unsedated gastroscopy has no influence on the outcomes of patients with gastric cancer: a retrospective study |
| title_fullStr | Sedated and unsedated gastroscopy has no influence on the outcomes of patients with gastric cancer: a retrospective study |
| title_full_unstemmed | Sedated and unsedated gastroscopy has no influence on the outcomes of patients with gastric cancer: a retrospective study |
| title_short | Sedated and unsedated gastroscopy has no influence on the outcomes of patients with gastric cancer: a retrospective study |
| title_sort | sedated and unsedated gastroscopy has no influence on the outcomes of patients with gastric cancer a retrospective study |
| topic | Anesthesia Gastric cancer Sedated gastroscopy Unsedated gastroscopy Comfort of gastroscopy |
| url | https://doi.org/10.1186/s12885-024-13413-0 |
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