U-shaped relationship between triglyceride glucose-body mass index and suicide attempts in Chinese patients with untreated first-episode major depressive disorder
Abstract Objective An alternative metric for evaluating insulin resistance (IR) is the triglyceride glucose-body mass index (TyG-BMI). However, it is yet unclear how TyG-BMI and suicide attempts (SA) are related. The objective of this research was to explore the correlation between the TyG-BMI index...
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2024-11-01
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| Online Access: | https://doi.org/10.1186/s12888-024-06269-y |
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| author | Fengnan Jia He Ma Junjun Liu Chuanwei Li Gang Ye Tao Chen Ruiping Huo Xiangdong Du Xiangyang Zhang |
| author_facet | Fengnan Jia He Ma Junjun Liu Chuanwei Li Gang Ye Tao Chen Ruiping Huo Xiangdong Du Xiangyang Zhang |
| author_sort | Fengnan Jia |
| collection | DOAJ |
| description | Abstract Objective An alternative metric for evaluating insulin resistance (IR) is the triglyceride glucose-body mass index (TyG-BMI). However, it is yet unclear how TyG-BMI and suicide attempts (SA) are related. The objective of this research was to explore the correlation between the TyG-BMI index and SA in individuals with untreated first-episode (UFE) major depressive disorder (MDD) in Shanxi Province. Methods This cross-sectional study was conducted from September 2016 to December 2018 in the psychiatric outpatient clinic of Taiyuan General Hospital and included 1718 patients with UFE MDD, with a mean age of 34.9 ± 12.4 years. The relationship between TyG-BMI and SA was assessed using logistic regression modeling. We investigated threshold effects using a two-piecewise linear regression model. Results Taking into consideration the potential influence of confounding variables, a comprehensive multivariate logistic regression analysis was conducted, which demonstrated the absence of a statistically significant association between the TyG-BMI index and the occurrence of SA, as evidenced by P-values that were all greater than 0.05. On the other hand, the visual analysis of the smoothed plots revealed a U-shaped relationship between the TyG-BMI index and the incidence of SA, with a notable inflection occurring at a TyG-BMI value of around 210. It was observed that the effect sizes flanking the inflection point, accompanied by their 95% confidence intervals, were 0.985 (95% CI: 0.972 to 0.999, P = 0.031) and 1.012 (95% CI: 1.003 to 1.047, P = 0.005), respectively. Conclusions In UFE MDD patients, a U-shaped link was observed between TyG-BMI and SA, with the minimal SA incidence noted at a TyG-BMI level of 210, signifying that an augmented risk for SA might be connected to both diminished and augmented TyG-BMI levels. |
| format | Article |
| id | doaj-art-a0b00519d5e3417ea1a760a897cfe2d9 |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | BMC Psychiatry |
| spelling | doaj-art-a0b00519d5e3417ea1a760a897cfe2d92024-11-17T12:40:25ZengBMCBMC Psychiatry1471-244X2024-11-0124111110.1186/s12888-024-06269-yU-shaped relationship between triglyceride glucose-body mass index and suicide attempts in Chinese patients with untreated first-episode major depressive disorderFengnan Jia0He Ma1Junjun Liu2Chuanwei Li3Gang Ye4Tao Chen5Ruiping Huo6Xiangdong Du7Xiangyang Zhang8Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversitySuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversityNanjing Meishan HospitalSuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversitySuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversitySuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversitySuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversitySuzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversityCAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of SciencesAbstract Objective An alternative metric for evaluating insulin resistance (IR) is the triglyceride glucose-body mass index (TyG-BMI). However, it is yet unclear how TyG-BMI and suicide attempts (SA) are related. The objective of this research was to explore the correlation between the TyG-BMI index and SA in individuals with untreated first-episode (UFE) major depressive disorder (MDD) in Shanxi Province. Methods This cross-sectional study was conducted from September 2016 to December 2018 in the psychiatric outpatient clinic of Taiyuan General Hospital and included 1718 patients with UFE MDD, with a mean age of 34.9 ± 12.4 years. The relationship between TyG-BMI and SA was assessed using logistic regression modeling. We investigated threshold effects using a two-piecewise linear regression model. Results Taking into consideration the potential influence of confounding variables, a comprehensive multivariate logistic regression analysis was conducted, which demonstrated the absence of a statistically significant association between the TyG-BMI index and the occurrence of SA, as evidenced by P-values that were all greater than 0.05. On the other hand, the visual analysis of the smoothed plots revealed a U-shaped relationship between the TyG-BMI index and the incidence of SA, with a notable inflection occurring at a TyG-BMI value of around 210. It was observed that the effect sizes flanking the inflection point, accompanied by their 95% confidence intervals, were 0.985 (95% CI: 0.972 to 0.999, P = 0.031) and 1.012 (95% CI: 1.003 to 1.047, P = 0.005), respectively. Conclusions In UFE MDD patients, a U-shaped link was observed between TyG-BMI and SA, with the minimal SA incidence noted at a TyG-BMI level of 210, signifying that an augmented risk for SA might be connected to both diminished and augmented TyG-BMI levels.https://doi.org/10.1186/s12888-024-06269-yMajor depressive disorderSuicide attemptsTriglyceride glucose-body mass indexInsulin resistance |
| spellingShingle | Fengnan Jia He Ma Junjun Liu Chuanwei Li Gang Ye Tao Chen Ruiping Huo Xiangdong Du Xiangyang Zhang U-shaped relationship between triglyceride glucose-body mass index and suicide attempts in Chinese patients with untreated first-episode major depressive disorder BMC Psychiatry Major depressive disorder Suicide attempts Triglyceride glucose-body mass index Insulin resistance |
| title | U-shaped relationship between triglyceride glucose-body mass index and suicide attempts in Chinese patients with untreated first-episode major depressive disorder |
| title_full | U-shaped relationship between triglyceride glucose-body mass index and suicide attempts in Chinese patients with untreated first-episode major depressive disorder |
| title_fullStr | U-shaped relationship between triglyceride glucose-body mass index and suicide attempts in Chinese patients with untreated first-episode major depressive disorder |
| title_full_unstemmed | U-shaped relationship between triglyceride glucose-body mass index and suicide attempts in Chinese patients with untreated first-episode major depressive disorder |
| title_short | U-shaped relationship between triglyceride glucose-body mass index and suicide attempts in Chinese patients with untreated first-episode major depressive disorder |
| title_sort | u shaped relationship between triglyceride glucose body mass index and suicide attempts in chinese patients with untreated first episode major depressive disorder |
| topic | Major depressive disorder Suicide attempts Triglyceride glucose-body mass index Insulin resistance |
| url | https://doi.org/10.1186/s12888-024-06269-y |
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