Alternative splicing of modulatory immune receptors in T lymphocytes: a newly identified and targetable mechanism for anticancer immunotherapy

Alternative splicing of modulatory immune receptors in T lymphocytes: a newly identified and targetable mechanism for anticancer immunotherapy

Alternative splicing (AS) is a mechanism that generates translational diversity within a genome. Equally important is the dynamic adaptability of the splicing machinery, which can give preference to one isoform over others encoded by a single gene. These isoform preferences change in response to the...

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Bibliographic Details
Main Authors: Shay Tzaban, Ori Stern, Elad Zisman, Galit Eisenberg, Shiri Klein, Shoshana Frankenburg, Michal Lotem
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
alternative splicing
cancer
immunotherapy
T lymphocytes
immune receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490035/full
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