The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies
The crosstalk between the tumour immune microenvironment (TIME) and tumour cells promote immune evasion and resistance to immunotherapy in gastrointestinal (GI) tumours. Post-transcriptional regulation of genes is pivotal to GI tumours progression, and RNA-binding proteins (RBPs) serve as key regula...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2024.2440683 |
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| _version_ | 1841554882589360128 |
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| author | Dongqi Li Xiangyu Chu Weikang Liu Yongsu Ma Xiaodong Tian Yinmo Yang |
| author_facet | Dongqi Li Xiangyu Chu Weikang Liu Yongsu Ma Xiaodong Tian Yinmo Yang |
| author_sort | Dongqi Li |
| collection | DOAJ |
| description | The crosstalk between the tumour immune microenvironment (TIME) and tumour cells promote immune evasion and resistance to immunotherapy in gastrointestinal (GI) tumours. Post-transcriptional regulation of genes is pivotal to GI tumours progression, and RNA-binding proteins (RBPs) serve as key regulators via their RNA-binding domains. RBPs may exhibit either anti-tumour or pro-tumour functions by influencing the TIME through the modulation of mRNAs and non-coding RNAs expression, as well as post-transcriptional modifications, primarily N6-methyladenosine (m6A). Aberrant regulation of RBPs, such as HuR and YBX1, typically enhances tumour immune escape and impacts prognosis of GI tumour patients. Further, while targeting RBPs offers a promising strategy for improving immunotherapy in GI cancers, the mechanisms by which RBPs regulate the TIME in these tumours remain poorly understood, and the therapeutic application is still in its early stages. This review summarizes current advances in exploring the roles of RBPs in regulating genes expression and their effect on the TIME of GI tumours, then providing theoretical insights for RBP-targeted cancer therapies. |
| format | Article |
| id | doaj-art-a096ab3cadae48c6bfb921142e7b5bf1 |
| institution | Kabale University |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-a096ab3cadae48c6bfb921142e7b5bf12025-01-08T08:54:39ZengTaylor & Francis GroupRNA Biology1547-62861555-85842025-12-0122111410.1080/15476286.2024.2440683The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignanciesDongqi Li0Xiangyu Chu1Weikang Liu2Yongsu Ma3Xiaodong Tian4Yinmo Yang5Department of Hepatobiliary and Pancreatic Surgery, Peking University First Hospital, Beijing, ChinaDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Peking University First Hospital, Beijing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Peking University First Hospital, Beijing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Peking University First Hospital, Beijing, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Peking University First Hospital, Beijing, ChinaThe crosstalk between the tumour immune microenvironment (TIME) and tumour cells promote immune evasion and resistance to immunotherapy in gastrointestinal (GI) tumours. Post-transcriptional regulation of genes is pivotal to GI tumours progression, and RNA-binding proteins (RBPs) serve as key regulators via their RNA-binding domains. RBPs may exhibit either anti-tumour or pro-tumour functions by influencing the TIME through the modulation of mRNAs and non-coding RNAs expression, as well as post-transcriptional modifications, primarily N6-methyladenosine (m6A). Aberrant regulation of RBPs, such as HuR and YBX1, typically enhances tumour immune escape and impacts prognosis of GI tumour patients. Further, while targeting RBPs offers a promising strategy for improving immunotherapy in GI cancers, the mechanisms by which RBPs regulate the TIME in these tumours remain poorly understood, and the therapeutic application is still in its early stages. This review summarizes current advances in exploring the roles of RBPs in regulating genes expression and their effect on the TIME of GI tumours, then providing theoretical insights for RBP-targeted cancer therapies.https://www.tandfonline.com/doi/10.1080/15476286.2024.2440683RNA binding proteinmRNAsncRNAstumour immune microenvironmentimmunotherapytargeted therapy |
| spellingShingle | Dongqi Li Xiangyu Chu Weikang Liu Yongsu Ma Xiaodong Tian Yinmo Yang The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies RNA Biology RNA binding protein mRNAs ncRNAs tumour immune microenvironment immunotherapy targeted therapy |
| title | The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies |
| title_full | The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies |
| title_fullStr | The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies |
| title_full_unstemmed | The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies |
| title_short | The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies |
| title_sort | regulatory roles of rna binding proteins in the tumour immune microenvironment of gastrointestinal malignancies |
| topic | RNA binding protein mRNAs ncRNAs tumour immune microenvironment immunotherapy targeted therapy |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2024.2440683 |
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