Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance
Acyl CoA binding protein (ACBP) encoded by DBI is a tissue hormone that limits autophagy in multiple cell types, hence acting as an extracellular autophagy checkpoint. We recently reported in Molecular Cancer that monoclonal antibodies neutralizing ACBP improve immunosurveillance of breast and lung...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | OncoImmunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2024.2413200 |
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| _version_ | 1846142212505600000 |
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| author | Léa Montégut Isabelle Martins Guido Kroemer |
| author_facet | Léa Montégut Isabelle Martins Guido Kroemer |
| author_sort | Léa Montégut |
| collection | DOAJ |
| description | Acyl CoA binding protein (ACBP) encoded by DBI is a tissue hormone that limits autophagy in multiple cell types, hence acting as an extracellular autophagy checkpoint. We recently reported in Molecular Cancer that monoclonal antibodies neutralizing ACBP improve immunosurveillance of breast and lung carcinomas. Moreover, ACBP neutralization improves the outcome of neoadjuvant chemoimmunotherapy with PD-1 blockade in preclinical models. |
| format | Article |
| id | doaj-art-a09535f849e24af8a4bb78fb65c7838b |
| institution | Kabale University |
| issn | 2162-402X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj-art-a09535f849e24af8a4bb78fb65c7838b2024-12-03T13:49:35ZengTaylor & Francis GroupOncoImmunology2162-402X2024-12-0113110.1080/2162402X.2024.2413200Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillanceLéa Montégut0Isabelle Martins1Guido Kroemer2Team Metabolism, Cancer and Immunity, Centre de Recherche des Cordeliers, INSERM U1138, Équipe Labellisée - Ligue Nationale contre le Cancer, Université Paris Cité, Sorbonne Université, Paris, FranceTeam Metabolism, Cancer and Immunity, Centre de Recherche des Cordeliers, INSERM U1138, Équipe Labellisée - Ligue Nationale contre le Cancer, Université Paris Cité, Sorbonne Université, Paris, FranceTeam Metabolism, Cancer and Immunity, Centre de Recherche des Cordeliers, INSERM U1138, Équipe Labellisée - Ligue Nationale contre le Cancer, Université Paris Cité, Sorbonne Université, Paris, FranceAcyl CoA binding protein (ACBP) encoded by DBI is a tissue hormone that limits autophagy in multiple cell types, hence acting as an extracellular autophagy checkpoint. We recently reported in Molecular Cancer that monoclonal antibodies neutralizing ACBP improve immunosurveillance of breast and lung carcinomas. Moreover, ACBP neutralization improves the outcome of neoadjuvant chemoimmunotherapy with PD-1 blockade in preclinical models.https://www.tandfonline.com/doi/10.1080/2162402X.2024.2413200Caloric restriction mimeticschemotherapyimmune checkpoint inhibitorimmunotherapy mammary carcinomanon-small cell lung cancer |
| spellingShingle | Léa Montégut Isabelle Martins Guido Kroemer Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance OncoImmunology Caloric restriction mimetics chemotherapy immune checkpoint inhibitor immunotherapy mammary carcinoma non-small cell lung cancer |
| title | Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance |
| title_full | Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance |
| title_fullStr | Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance |
| title_full_unstemmed | Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance |
| title_short | Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance |
| title_sort | acyl coa binding protein acbp an autophagy checkpoint that can be targeted for improving cancer immunosurveillance |
| topic | Caloric restriction mimetics chemotherapy immune checkpoint inhibitor immunotherapy mammary carcinoma non-small cell lung cancer |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2024.2413200 |
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