Prevalence of keratoconus and keratoconus suspect, and their characteristics on corneal tomography in a population-based study.
Keratoconus (KC) is a progressive corneal disorder resulting in severe visual impairment. We aimed to determine the prevalence and corneal tomographic characteristics of KC and keratoconus suspect (KCS) in a population-based study, and to construct discrimination models with or without corneal tomog...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0308892 |
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| author | Hiroyuki Namba Naoyuki Maeda Hiroshi Utsunomiya Yutaka Kaneko Kenichi Ishizawa Yoshiyuki Ueno Koichi Nishitsuka |
| author_facet | Hiroyuki Namba Naoyuki Maeda Hiroshi Utsunomiya Yutaka Kaneko Kenichi Ishizawa Yoshiyuki Ueno Koichi Nishitsuka |
| author_sort | Hiroyuki Namba |
| collection | DOAJ |
| description | Keratoconus (KC) is a progressive corneal disorder resulting in severe visual impairment. We aimed to determine the prevalence and corneal tomographic characteristics of KC and keratoconus suspect (KCS) in a population-based study, and to construct discrimination models with or without corneal tomography. A total of 1,544 eyes (822 participants aged ≥35 years) were evaluated using data from the Yamagata Study (2015-2017). Systemic and ophthalmological examinations including corneal tomography with swept-source anterior segment optical coherence tomography (AS-OCT) were conducted to determine the prevalence and corneal tomographic characteristics of KC and KCS. In addition, data on 766 eyes were used to construct discrimination models with or without corneal tomography. In results, KC was diagnosed in six (0.85%) participants, and KCS was diagnosed in 27 (1.46%) participants. The values including corneal power, keratometric cylinder, corneal central and thinnest thickness, corneal asymmetry, higher-order irregularity, and their inter-eye differences were associated with KC and KCS. The areas under the receiver operating characteristic curves for the three multivariate discrimination models (without corneal tomography, with corneal tomography, and without corneal tomography + inter-eye difference models) for participants with KC or KCS were 0.848, 1.000, and 0.930, respectively. When corneal tomography is unavailable, inter-eye differences in corneal parameters may be useful screening tools for KC and KCS. |
| format | Article |
| id | doaj-art-a093332bcee6434fba8fa8e2d68381a1 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-a093332bcee6434fba8fa8e2d68381a12025-08-20T03:52:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e030889210.1371/journal.pone.0308892Prevalence of keratoconus and keratoconus suspect, and their characteristics on corneal tomography in a population-based study.Hiroyuki NambaNaoyuki MaedaHiroshi UtsunomiyaYutaka KanekoKenichi IshizawaYoshiyuki UenoKoichi NishitsukaKeratoconus (KC) is a progressive corneal disorder resulting in severe visual impairment. We aimed to determine the prevalence and corneal tomographic characteristics of KC and keratoconus suspect (KCS) in a population-based study, and to construct discrimination models with or without corneal tomography. A total of 1,544 eyes (822 participants aged ≥35 years) were evaluated using data from the Yamagata Study (2015-2017). Systemic and ophthalmological examinations including corneal tomography with swept-source anterior segment optical coherence tomography (AS-OCT) were conducted to determine the prevalence and corneal tomographic characteristics of KC and KCS. In addition, data on 766 eyes were used to construct discrimination models with or without corneal tomography. In results, KC was diagnosed in six (0.85%) participants, and KCS was diagnosed in 27 (1.46%) participants. The values including corneal power, keratometric cylinder, corneal central and thinnest thickness, corneal asymmetry, higher-order irregularity, and their inter-eye differences were associated with KC and KCS. The areas under the receiver operating characteristic curves for the three multivariate discrimination models (without corneal tomography, with corneal tomography, and without corneal tomography + inter-eye difference models) for participants with KC or KCS were 0.848, 1.000, and 0.930, respectively. When corneal tomography is unavailable, inter-eye differences in corneal parameters may be useful screening tools for KC and KCS.https://doi.org/10.1371/journal.pone.0308892 |
| spellingShingle | Hiroyuki Namba Naoyuki Maeda Hiroshi Utsunomiya Yutaka Kaneko Kenichi Ishizawa Yoshiyuki Ueno Koichi Nishitsuka Prevalence of keratoconus and keratoconus suspect, and their characteristics on corneal tomography in a population-based study. PLoS ONE |
| title | Prevalence of keratoconus and keratoconus suspect, and their characteristics on corneal tomography in a population-based study. |
| title_full | Prevalence of keratoconus and keratoconus suspect, and their characteristics on corneal tomography in a population-based study. |
| title_fullStr | Prevalence of keratoconus and keratoconus suspect, and their characteristics on corneal tomography in a population-based study. |
| title_full_unstemmed | Prevalence of keratoconus and keratoconus suspect, and their characteristics on corneal tomography in a population-based study. |
| title_short | Prevalence of keratoconus and keratoconus suspect, and their characteristics on corneal tomography in a population-based study. |
| title_sort | prevalence of keratoconus and keratoconus suspect and their characteristics on corneal tomography in a population based study |
| url | https://doi.org/10.1371/journal.pone.0308892 |
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