Sex differences in the association between fasting glucose and ischemic stroke incidence in people without diabetes: a 19-year prospective cohort study in Korea
This study aimed to determine whether high fasting blood glucose (FBG) levels are a risk factor for ischemic stroke (IS) in the population without diabetes and conduct an interaction analysis to explore the potential differential effects of FBG levels and sex on IS risk. We used data from the Gen...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MRE Press
2024-12-01
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| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | https://oss.jomh.org/files/article/20241230-452/pdf/JOMH2024082501.pdf |
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| Summary: | This study aimed to determine whether high fasting blood glucose (FBG) levels
are a risk factor for ischemic stroke (IS) in the population without diabetes and
conduct an interaction analysis to explore the potential differential effects of
FBG levels and sex on IS risk. We used data from the Genome and Epidemiology
Study (KoGES). The primary exposure was serum FBG obtained at the first
interview. The main outcome was the occurrence of IS in the biennial follow-up
surveys. Cox proportional regression analysis was performed to estimate the
effects of high FBG on IS incidence. We performed an interaction analysis to
examine the effect of FBG and sex interaction on the incidence of IS. Over the
18-year follow-up period, which included 5682 participants, 333 cases of newly
diagnosed IS were recorded, equivalent to 5.5 cases per 1000 person-years.
Elevated FBG levels did not show a significant impact on IS incidence, with an
adjusted hazard ratio (aHR) of 1.06 (95% confidence interval (CI): 0.89–1.26).
However, in the interaction analysis, elevated FBG was linked to a higher IS risk
in females (aHR: 1.40; 95% CI: 1.03–1.92), while no statistically significant
association was observed in males (aHR: 1.07; 95% CI: 0.87–1.48). In the
population without diabetes, high FBG (≥100 mg/dL) was associated with an
increased risk of IS only in females. This conclusion underscores the need for
sex-specific strategies in managing and mitigating the risk of IS associated with
high FBG. Even in the absence of diabetes, carefully monitoring and managing high
FBG are crucial. |
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| ISSN: | 1875-6867 1875-6859 |