The Impact of Probiotics in Respiratory Diseases
Probiotics are viable microorganisms that, if adequately administered, confer great benefits to the host for the prevention or treatment of a wide range of human diseases, including recurrent respiratory tract infection (RRTI), cystic fibrosis, allergies, and chronic obstructive pulmonary disease (C...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Erbil Polytechnic University
2020-06-01
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| Series: | Polytechnic |
| Subjects: | |
| Online Access: | https://polytechnic-journal.epu.edu.iq/home/vol10/iss1/25 |
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| Summary: | Probiotics are viable microorganisms that, if adequately administered, confer great benefits to the host
for the prevention or treatment of a wide range of human diseases, including recurrent respiratory
tract infection (RRTI), cystic fibrosis, allergies, and chronic obstructive pulmonary disease (COPD).
One of the current problems is that the overuse of antibiotics during respiratory tract infection has
led to increased resistance to them, which has been demonstrated in numerous examinations that
specific lactic acid bacteria (LAB), one of the key probiotics, against bacterial and viral infections of
the respiratory and gastrointestinal tract, have a protective effect. On the other hand, changes in
the gastrointestinal and respiratory microbiomes, especially lactobacilli and bifidobacteria, lead to an
increase in allergies and asthma and a balance in the microbiome may improve symptoms. Probiotics
are able to increase the number and activity of leukocytes, neutrophils, and NK cells. They can also
increase IL-10 expression and decrease the expression of inflammatory cytokines such as TNF-α, IL-1β,
and IL-8. In addition, they maintain high levels of IgA and produce bacteriocin and ruterin that have
antimicrobial activity. Without identifying the specific properties of the probiotic strains and identifying
the precise mechanism of their action, probiotic treatment would only be a large hypothesis because
the therapeutic and clinical outcomes are different. On the other hand, metagenomics have provided
information on how the microbiome interacts with host physiology, leading to new therapeutic targets. |
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| ISSN: | 2707-7799 |