Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland
Objectives To assess the association between the intensity of statin therapy and the level of physical activity in patients 1 year after an acute coronary syndrome (ACS).Design Prospective cohort study from the Special Program University Medicine-Acute Coronary Syndromes.Setting Four university hosp...
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/1/e088262.full |
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| author | David Nanchen Stephan Windecker Isabella Locatelli Nicolas Rodondi Lorenz Räber David Carballo Francois Mach Olivier Muller Baris Gencer Christian M Matter Roland Klingenberg Thomas Lüscher Alex Boudon |
| author_facet | David Nanchen Stephan Windecker Isabella Locatelli Nicolas Rodondi Lorenz Räber David Carballo Francois Mach Olivier Muller Baris Gencer Christian M Matter Roland Klingenberg Thomas Lüscher Alex Boudon |
| author_sort | David Nanchen |
| collection | DOAJ |
| description | Objectives To assess the association between the intensity of statin therapy and the level of physical activity in patients 1 year after an acute coronary syndrome (ACS).Design Prospective cohort study from the Special Program University Medicine-Acute Coronary Syndromes.Setting Four university hospital centres in Switzerland.Participants 2274 patients with a main diagnosis of ACS between 2009 and 2017 who were available for a 1-year follow-up visit 1 year after hospital discharge.Outcome measures Self-reported physical activity was assessed with the International Physical Activity Questionnaire. The level of physical activity in metabolic equivalent-minutes per week (MET-min/week) was first stratified into sedentary and physically active categories and then analysed continuously among physically active patients. Analyses were performed using a propensity score weighting approach.Results One year after ACS, 1222 (53.7%) patients were on high-intensity statin therapy, 890 (39.1%) were on low/moderate-intensity statin therapy and 162 (7.1%) were not on statin therapy. Compared with non-statin users, low-/moderate-intensity statin users and high-intensity statin users were more likely to be physically active than sedentary, with a fully adjusted OR of 2.86 (95% CI 1.12 to 7.26) and 4.52 (95% CI 1.68 to 12.20), respectively. Among physically active patients, physical activity level was similar across all statin user categories, with median levels of 2792.5, 2712.0 and 2839.5 MET-min/week in non-statin, moderate/low-statin and high-statin users, respectively (p=0.307).Conclusions One year after ACS, neither low-/moderate-intensity nor high-intensity statin uses were associated with reduced self-reported physical activity compared with non-statin use. The concern that statin therapy may impair physical activity among ACS patients was not confirmed in this study. |
| format | Article |
| id | doaj-art-a076f2772a13453e939dabbb31ca02f4 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-a076f2772a13453e939dabbb31ca02f42025-01-17T19:50:09ZengBMJ Publishing GroupBMJ Open2044-60552025-01-0115110.1136/bmjopen-2024-088262Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in SwitzerlandDavid Nanchen0Stephan Windecker1Isabella Locatelli2Nicolas Rodondi3Lorenz Räber4David Carballo5Francois Mach6Olivier Muller7Baris Gencer8Christian M Matter9Roland Klingenberg10Thomas Lüscher11Alex Boudon1213 Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland6 Department of Cardiology, Inselspital Universitatsspital Bern, Bern, Switzerland1 Center for Primary Care and Public Health (Unisanté), University of Lausanne Faculty of Biology and Medicine, Lausanne, Vaud, Switzerland7 Department of General Internal Medicine, Inselspital Universitatsspital Bern, Bern, Switzerland6 Department of Cardiology, Inselspital Universitatsspital Bern, Bern, Switzerland4 Division of Cardiology, University of Geneva, Geneva, Switzerland11 Service de Cardiologie, Universite de Geneve Faculte de Medecine, Geneve, Switzerland12 Lausanne University Hospital, Lausanne, Switzerland2 Division of Cardiology, Faculty of Medicine, University of Geneva, Geneve, Switzerland10 Department of Cardiology, University Heart Center, Universitat Zurich Medizinische Fakultat, Zurich, Switzerland5 Department of Cardiology, University of Zurich, Zurich, Switzerland9 Royal Brompton and Harefield NHS Trust, London, UK1 Center for Primary Care and Public Health (Unisanté), University of Lausanne Faculty of Biology and Medicine, Lausanne, Vaud, SwitzerlandObjectives To assess the association between the intensity of statin therapy and the level of physical activity in patients 1 year after an acute coronary syndrome (ACS).Design Prospective cohort study from the Special Program University Medicine-Acute Coronary Syndromes.Setting Four university hospital centres in Switzerland.Participants 2274 patients with a main diagnosis of ACS between 2009 and 2017 who were available for a 1-year follow-up visit 1 year after hospital discharge.Outcome measures Self-reported physical activity was assessed with the International Physical Activity Questionnaire. The level of physical activity in metabolic equivalent-minutes per week (MET-min/week) was first stratified into sedentary and physically active categories and then analysed continuously among physically active patients. Analyses were performed using a propensity score weighting approach.Results One year after ACS, 1222 (53.7%) patients were on high-intensity statin therapy, 890 (39.1%) were on low/moderate-intensity statin therapy and 162 (7.1%) were not on statin therapy. Compared with non-statin users, low-/moderate-intensity statin users and high-intensity statin users were more likely to be physically active than sedentary, with a fully adjusted OR of 2.86 (95% CI 1.12 to 7.26) and 4.52 (95% CI 1.68 to 12.20), respectively. Among physically active patients, physical activity level was similar across all statin user categories, with median levels of 2792.5, 2712.0 and 2839.5 MET-min/week in non-statin, moderate/low-statin and high-statin users, respectively (p=0.307).Conclusions One year after ACS, neither low-/moderate-intensity nor high-intensity statin uses were associated with reduced self-reported physical activity compared with non-statin use. The concern that statin therapy may impair physical activity among ACS patients was not confirmed in this study.https://bmjopen.bmj.com/content/15/1/e088262.full |
| spellingShingle | David Nanchen Stephan Windecker Isabella Locatelli Nicolas Rodondi Lorenz Räber David Carballo Francois Mach Olivier Muller Baris Gencer Christian M Matter Roland Klingenberg Thomas Lüscher Alex Boudon Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland BMJ Open |
| title | Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland |
| title_full | Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland |
| title_fullStr | Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland |
| title_full_unstemmed | Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland |
| title_short | Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland |
| title_sort | association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome a multicentre prospective cohort study in switzerland |
| url | https://bmjopen.bmj.com/content/15/1/e088262.full |
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