Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival
Flap techniques are indispensable in modern surgery because of their role in repairing tissue defects and restoring function. Ischemia-reperfusion and oxidative stress-induced injuries are the main causes of flap failure. Oxidative stress exacerbates cell damage through the accumulation of reactive...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004939 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841533252509106176 |
|---|---|
| author | Xiangjun Liu Yikun Ju Pu Yang Naisi Shen Yunyuan Shao Anqi Yang Rui Wu Lanjie Lei Bairong Fang |
| author_facet | Xiangjun Liu Yikun Ju Pu Yang Naisi Shen Yunyuan Shao Anqi Yang Rui Wu Lanjie Lei Bairong Fang |
| author_sort | Xiangjun Liu |
| collection | DOAJ |
| description | Flap techniques are indispensable in modern surgery because of their role in repairing tissue defects and restoring function. Ischemia-reperfusion and oxidative stress-induced injuries are the main causes of flap failure. Oxidative stress exacerbates cell damage through the accumulation of reactive oxygen species (ROS), thereby affecting flap function and survival. Effective management of these factors is essential for improving flap survival and post-operative recovery. In this study, we utilized hollow mesoporous cerium dioxide nanoparticles loaded with quercetin, which were later loaded into a light-cured double cross-linked hydrogel (HQu@BC) and injected into the flap site to activate macrophage reprogramming to maintain local ROS homeostasis and reduce inflammation. Quercetin scavenges ROS and reduces mitochondrial oxidative stress due to its intrinsic reducing structures such as catechols, carbon-carbon double bonds, and hydroxyl synergistic mesoporous cerium dioxide nanoparticles, and inhibits inflammation by suppressing M1 macrophage polarization. This system continuously regulates ROS levels, kills bacteria and ultimately reduces inflammation, thereby creating a favorable microenvironment for flap survival. This innovative injectable composite nanoparticle hydrogel material has anti-inflammatory, antioxidant, antimicrobial, and healing-promoting properties, providing a new approach to improving the success of flap surgery. |
| format | Article |
| id | doaj-art-a0723a100872446d8c0389dc2ed63272 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-a0723a100872446d8c0389dc2ed632722025-01-17T04:52:12ZengElsevierMaterials Today Bio2590-00642025-02-0130101432Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survivalXiangjun Liu0Yikun Ju1Pu Yang2Naisi Shen3Yunyuan Shao4Anqi Yang5Rui Wu6Lanjie Lei7Bairong Fang8Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, ChinaDepartment of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, ChinaDepartment of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, ChinaDepartment of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, 310015, ChinaDepartment of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, ChinaDepartment of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, 310015, China; Corresponding author.Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China; Corresponding author.Flap techniques are indispensable in modern surgery because of their role in repairing tissue defects and restoring function. Ischemia-reperfusion and oxidative stress-induced injuries are the main causes of flap failure. Oxidative stress exacerbates cell damage through the accumulation of reactive oxygen species (ROS), thereby affecting flap function and survival. Effective management of these factors is essential for improving flap survival and post-operative recovery. In this study, we utilized hollow mesoporous cerium dioxide nanoparticles loaded with quercetin, which were later loaded into a light-cured double cross-linked hydrogel (HQu@BC) and injected into the flap site to activate macrophage reprogramming to maintain local ROS homeostasis and reduce inflammation. Quercetin scavenges ROS and reduces mitochondrial oxidative stress due to its intrinsic reducing structures such as catechols, carbon-carbon double bonds, and hydroxyl synergistic mesoporous cerium dioxide nanoparticles, and inhibits inflammation by suppressing M1 macrophage polarization. This system continuously regulates ROS levels, kills bacteria and ultimately reduces inflammation, thereby creating a favorable microenvironment for flap survival. This innovative injectable composite nanoparticle hydrogel material has anti-inflammatory, antioxidant, antimicrobial, and healing-promoting properties, providing a new approach to improving the success of flap surgery.http://www.sciencedirect.com/science/article/pii/S2590006424004939QuercetinCerium dioxideSkin flapOxidative stress |
| spellingShingle | Xiangjun Liu Yikun Ju Pu Yang Naisi Shen Yunyuan Shao Anqi Yang Rui Wu Lanjie Lei Bairong Fang Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival Materials Today Bio Quercetin Cerium dioxide Skin flap Oxidative stress |
| title | Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival |
| title_full | Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival |
| title_fullStr | Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival |
| title_full_unstemmed | Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival |
| title_short | Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival |
| title_sort | enhanced hydrogel loading of quercetin loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival |
| topic | Quercetin Cerium dioxide Skin flap Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004939 |
| work_keys_str_mv | AT xiangjunliu enhancedhydrogelloadingofquercetinloadedhollowmesoporousceriumdioxidenanoparticlesforskinflapsurvival AT yikunju enhancedhydrogelloadingofquercetinloadedhollowmesoporousceriumdioxidenanoparticlesforskinflapsurvival AT puyang enhancedhydrogelloadingofquercetinloadedhollowmesoporousceriumdioxidenanoparticlesforskinflapsurvival AT naisishen enhancedhydrogelloadingofquercetinloadedhollowmesoporousceriumdioxidenanoparticlesforskinflapsurvival AT yunyuanshao enhancedhydrogelloadingofquercetinloadedhollowmesoporousceriumdioxidenanoparticlesforskinflapsurvival AT anqiyang enhancedhydrogelloadingofquercetinloadedhollowmesoporousceriumdioxidenanoparticlesforskinflapsurvival AT ruiwu enhancedhydrogelloadingofquercetinloadedhollowmesoporousceriumdioxidenanoparticlesforskinflapsurvival AT lanjielei enhancedhydrogelloadingofquercetinloadedhollowmesoporousceriumdioxidenanoparticlesforskinflapsurvival AT bairongfang enhancedhydrogelloadingofquercetinloadedhollowmesoporousceriumdioxidenanoparticlesforskinflapsurvival |