Primary HSV-2 Infection in an Immunocompromised Patient Reveals High Diversity of Drug-Resistance Mutations in the Viral DNA Polymerase

Primary HSV-2 Infection in an Immunocompromised Patient Reveals High Diversity of Drug-Resistance Mutations in the Viral DNA Polymerase

Herpes simplex virus 2 (HSV-2) remains a significant cause of morbidity and mortality in immunocompromised individuals, despite the availability of effective antivirals. Infections caused by drug-resistant isolates are an emerging concern among these patients. Understanding evolutionary aspects of H...

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Bibliographic Details
Main Authors: Hanna Helena Schalkwijk, Sarah Gillemot, Emilie Frobert, Florence Morfin, Sophie Ducastelle, Anne Conrad, Pierre Fiten, Ghislain Opdenakker, Robert Snoeck, Graciela Andrei
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Viruses
Subjects:
herpes simplex virus 2
drug resistance
viral heterogeneity
viral fitness
Online Access:https://www.mdpi.com/1999-4915/17/7/962
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