Pathogenesis and current status of the treatment of lung cancer associated with idiopathic pulmonary fibrosis
Abstract Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with chronic progressive fibrosis of unknown etiology; it is characterized by persistent fibrosis of the lungs accompanied by irreversible lung function decline and high mortality rates. A large body of evidence suggests a...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Respiratory Research |
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| Online Access: | https://doi.org/10.1186/s12931-025-03294-7 |
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| author | Yuanyuan Zhang Chang Qi Qi Wei Yalun Li Panwen Tian |
| author_facet | Yuanyuan Zhang Chang Qi Qi Wei Yalun Li Panwen Tian |
| author_sort | Yuanyuan Zhang |
| collection | DOAJ |
| description | Abstract Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with chronic progressive fibrosis of unknown etiology; it is characterized by persistent fibrosis of the lungs accompanied by irreversible lung function decline and high mortality rates. A large body of evidence suggests a significant association between IPF and lung cancer (LC). IPF itself increases the risk of LC development, and LC associated with IPF often originates in areas of honeycomb lesions in IPF. In addition, there are similarities between the two diseases in terms of genetics as well as cellular molecular mechanisms; examples include genetic and epigenetic variants, fibroblast activation and proliferation, epithelial‒mesenchymal transition (EMT), abnormal mechanical forces generated in the lungs, and aberrant signaling pathway activation, which may drive the progression of pathology in both diseases. In this review, we describe in detail the epidemiological and clinical associations of LC in patients with IPF, highlight recent studies on the shared pathogenesis between IPF and LC, and discuss current advances in the treatment of LC associated with idiopathic pulmonary fibrosis. |
| format | Article |
| id | doaj-art-a06879475e694d0c98c7cf6e4d13d369 |
| institution | Kabale University |
| issn | 1465-993X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj-art-a06879475e694d0c98c7cf6e4d13d3692025-08-20T04:01:41ZengBMCRespiratory Research1465-993X2025-07-0126112110.1186/s12931-025-03294-7Pathogenesis and current status of the treatment of lung cancer associated with idiopathic pulmonary fibrosisYuanyuan Zhang0Chang Qi1Qi Wei2Yalun Li3Panwen Tian4Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan UniversityAbstract Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with chronic progressive fibrosis of unknown etiology; it is characterized by persistent fibrosis of the lungs accompanied by irreversible lung function decline and high mortality rates. A large body of evidence suggests a significant association between IPF and lung cancer (LC). IPF itself increases the risk of LC development, and LC associated with IPF often originates in areas of honeycomb lesions in IPF. In addition, there are similarities between the two diseases in terms of genetics as well as cellular molecular mechanisms; examples include genetic and epigenetic variants, fibroblast activation and proliferation, epithelial‒mesenchymal transition (EMT), abnormal mechanical forces generated in the lungs, and aberrant signaling pathway activation, which may drive the progression of pathology in both diseases. In this review, we describe in detail the epidemiological and clinical associations of LC in patients with IPF, highlight recent studies on the shared pathogenesis between IPF and LC, and discuss current advances in the treatment of LC associated with idiopathic pulmonary fibrosis.https://doi.org/10.1186/s12931-025-03294-7Idiopathic pulmonary fibrosis (IPF)Lung cancer (LC)PathogenesisTreatment |
| spellingShingle | Yuanyuan Zhang Chang Qi Qi Wei Yalun Li Panwen Tian Pathogenesis and current status of the treatment of lung cancer associated with idiopathic pulmonary fibrosis Respiratory Research Idiopathic pulmonary fibrosis (IPF) Lung cancer (LC) Pathogenesis Treatment |
| title | Pathogenesis and current status of the treatment of lung cancer associated with idiopathic pulmonary fibrosis |
| title_full | Pathogenesis and current status of the treatment of lung cancer associated with idiopathic pulmonary fibrosis |
| title_fullStr | Pathogenesis and current status of the treatment of lung cancer associated with idiopathic pulmonary fibrosis |
| title_full_unstemmed | Pathogenesis and current status of the treatment of lung cancer associated with idiopathic pulmonary fibrosis |
| title_short | Pathogenesis and current status of the treatment of lung cancer associated with idiopathic pulmonary fibrosis |
| title_sort | pathogenesis and current status of the treatment of lung cancer associated with idiopathic pulmonary fibrosis |
| topic | Idiopathic pulmonary fibrosis (IPF) Lung cancer (LC) Pathogenesis Treatment |
| url | https://doi.org/10.1186/s12931-025-03294-7 |
| work_keys_str_mv | AT yuanyuanzhang pathogenesisandcurrentstatusofthetreatmentoflungcancerassociatedwithidiopathicpulmonaryfibrosis AT changqi pathogenesisandcurrentstatusofthetreatmentoflungcancerassociatedwithidiopathicpulmonaryfibrosis AT qiwei pathogenesisandcurrentstatusofthetreatmentoflungcancerassociatedwithidiopathicpulmonaryfibrosis AT yalunli pathogenesisandcurrentstatusofthetreatmentoflungcancerassociatedwithidiopathicpulmonaryfibrosis AT panwentian pathogenesisandcurrentstatusofthetreatmentoflungcancerassociatedwithidiopathicpulmonaryfibrosis |