Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat
Abstract Background The anesthetic states are accompanied by functional alterations. However, the dose-related adaptive alterations in the higher-order network under anesthesia, e. g. default mode network (DMN), are poorly revealed. Methods We implanted electrodes in brain regions of the rat DMN to...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-023-02153-6 |
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| author | Fengru Guo Yuqin Li Zhaoxin Jian Yan Cui Wenhui Gong Airui Li Wei Jing Peng Xu Ke Chen Daqing Guo Dezhong Yao Yang Xia |
| author_facet | Fengru Guo Yuqin Li Zhaoxin Jian Yan Cui Wenhui Gong Airui Li Wei Jing Peng Xu Ke Chen Daqing Guo Dezhong Yao Yang Xia |
| author_sort | Fengru Guo |
| collection | DOAJ |
| description | Abstract Background The anesthetic states are accompanied by functional alterations. However, the dose-related adaptive alterations in the higher-order network under anesthesia, e. g. default mode network (DMN), are poorly revealed. Methods We implanted electrodes in brain regions of the rat DMN to acquire local field potentials to investigate the perturbations produced by anesthesia. Relative power spectral density, static functional connectivity (FC), fuzzy entropy of dynamic FC, and topological features were computed from the data. Results The results showed that adaptive reconstruction was induced by isoflurane, exhibiting reduced static and stable long-range FC, and altered topological features. These reconstruction patterns were in a dose-related fashion. Conclusion These results might impart insights into the neural network mechanisms underlying anesthesia and suggest the potential of monitoring the depth of anesthesia based on the parameters of DMN. |
| format | Article |
| id | doaj-art-a03c5980d61447a8b0f64254eacf0bfd |
| institution | Kabale University |
| issn | 1471-2253 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj-art-a03c5980d61447a8b0f64254eacf0bfd2024-12-29T12:44:42ZengBMCBMC Anesthesiology1471-22532023-06-0123111210.1186/s12871-023-02153-6Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the ratFengru Guo0Yuqin Li1Zhaoxin Jian2Yan Cui3Wenhui Gong4Airui Li5Wei Jing6Peng Xu7Ke Chen8Daqing Guo9Dezhong Yao10Yang Xia11Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaAbstract Background The anesthetic states are accompanied by functional alterations. However, the dose-related adaptive alterations in the higher-order network under anesthesia, e. g. default mode network (DMN), are poorly revealed. Methods We implanted electrodes in brain regions of the rat DMN to acquire local field potentials to investigate the perturbations produced by anesthesia. Relative power spectral density, static functional connectivity (FC), fuzzy entropy of dynamic FC, and topological features were computed from the data. Results The results showed that adaptive reconstruction was induced by isoflurane, exhibiting reduced static and stable long-range FC, and altered topological features. These reconstruction patterns were in a dose-related fashion. Conclusion These results might impart insights into the neural network mechanisms underlying anesthesia and suggest the potential of monitoring the depth of anesthesia based on the parameters of DMN.https://doi.org/10.1186/s12871-023-02153-6IsofluraneDefault mode network |
| spellingShingle | Fengru Guo Yuqin Li Zhaoxin Jian Yan Cui Wenhui Gong Airui Li Wei Jing Peng Xu Ke Chen Daqing Guo Dezhong Yao Yang Xia Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat BMC Anesthesiology Isoflurane Default mode network |
| title | Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat |
| title_full | Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat |
| title_fullStr | Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat |
| title_full_unstemmed | Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat |
| title_short | Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat |
| title_sort | dose related adaptive reconstruction of dmn in isoflurane administration a study in the rat |
| topic | Isoflurane Default mode network |
| url | https://doi.org/10.1186/s12871-023-02153-6 |
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