Pleomorphic Adenoma versus Basal Cell Adenoma: An immunohistochemical analysis with b-catenin
The objective of this study was to investigate the distribution of b-catenin in pleomorphic adenomas and the basal cell adenomas to clarify its possible role in the etiopathogenesis of these two lesions. The expression of b-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry...
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| Format: | Article |
| Language: | English |
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Universidade Estadual Paulista
2014-01-01
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| Series: | Brazilian Dental Science |
| Online Access: | https://ojs.ict.unesp.br/index.php/cob/article/view/944 |
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| author | Renata Falchete do Prado Camila Lopes Cardoso Alberto Consolaro Antonio Luis Assis Taveira |
| author_facet | Renata Falchete do Prado Camila Lopes Cardoso Alberto Consolaro Antonio Luis Assis Taveira |
| author_sort | Renata Falchete do Prado |
| collection | DOAJ |
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The objective of this study was to investigate the distribution of b-catenin in pleomorphic adenomas and the basal cell adenomas to clarify its possible role in the etiopathogenesis of these two lesions. The expression of b-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin-embedded specimens by the avidin-biotin-peroxidase complex method in 10 pleomorphic adenomas and 2 basal cell adenomas. The specimens were analyzed taking into account intensity, distribution and association with myoepithelial cells. The results showed that all cases of pleomorphic adenomas exhibited membranous and cytoplasmic immunostaining and the 2 cases of basal cell adenomas displayed nuclear staining. Higher b-catenin index rates were seen mainly in ductal structures of pleomorphic adenomas and in the nuclei of myoepithelial stromal and myoepithelial cells of solid clusters in basal cell adenomas. In conclusion, this immunohistochemical study may suggests the different degree of differentiation of the myoepithelial cells in these two tumors.
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| format | Article |
| id | doaj-art-a02653daf7e54b59af1153e9f51eb525 |
| institution | Kabale University |
| issn | 2178-6011 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Brazilian Dental Science |
| spelling | doaj-art-a02653daf7e54b59af1153e9f51eb5252025-08-22T17:55:00ZengUniversidade Estadual PaulistaBrazilian Dental Science2178-60112014-01-0117110.14295/bds.2014.v17i1.944Pleomorphic Adenoma versus Basal Cell Adenoma: An immunohistochemical analysis with b-cateninRenata Falchete do Prado0Camila Lopes Cardoso1Alberto Consolaro2Antonio Luis Assis Taveira3Institute of Science and Technology – UNESP – Univ Estadual Paulista – School of Dentistry – Department of Bioscience and Oral Diagnosis – São José dos Campos – SP – Brazil.University of Sao Paulo – USP – Bauru Dental School – Bauru – SP – Brazil.University of Sao Paulo – USP – Bauru Dental School – Department of Stomatology – Bauru – SP – Brazil.University of Sao Paulo – USP – Bauru Dental School – Department of Stomatology – Bauru – SP – Brazil. The objective of this study was to investigate the distribution of b-catenin in pleomorphic adenomas and the basal cell adenomas to clarify its possible role in the etiopathogenesis of these two lesions. The expression of b-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin-embedded specimens by the avidin-biotin-peroxidase complex method in 10 pleomorphic adenomas and 2 basal cell adenomas. The specimens were analyzed taking into account intensity, distribution and association with myoepithelial cells. The results showed that all cases of pleomorphic adenomas exhibited membranous and cytoplasmic immunostaining and the 2 cases of basal cell adenomas displayed nuclear staining. Higher b-catenin index rates were seen mainly in ductal structures of pleomorphic adenomas and in the nuclei of myoepithelial stromal and myoepithelial cells of solid clusters in basal cell adenomas. In conclusion, this immunohistochemical study may suggests the different degree of differentiation of the myoepithelial cells in these two tumors. https://ojs.ict.unesp.br/index.php/cob/article/view/944 |
| spellingShingle | Renata Falchete do Prado Camila Lopes Cardoso Alberto Consolaro Antonio Luis Assis Taveira Pleomorphic Adenoma versus Basal Cell Adenoma: An immunohistochemical analysis with b-catenin Brazilian Dental Science |
| title | Pleomorphic Adenoma versus Basal Cell Adenoma: An immunohistochemical analysis with b-catenin |
| title_full | Pleomorphic Adenoma versus Basal Cell Adenoma: An immunohistochemical analysis with b-catenin |
| title_fullStr | Pleomorphic Adenoma versus Basal Cell Adenoma: An immunohistochemical analysis with b-catenin |
| title_full_unstemmed | Pleomorphic Adenoma versus Basal Cell Adenoma: An immunohistochemical analysis with b-catenin |
| title_short | Pleomorphic Adenoma versus Basal Cell Adenoma: An immunohistochemical analysis with b-catenin |
| title_sort | pleomorphic adenoma versus basal cell adenoma an immunohistochemical analysis with b catenin |
| url | https://ojs.ict.unesp.br/index.php/cob/article/view/944 |
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