Shared Gene Expression Dysregulation Across Subtypes of Sanfilippo and Morquio Diseases: The Role of PFN1 in Regulating Glycosaminoglycan Levels

Shared Gene Expression Dysregulation Across Subtypes of Sanfilippo and Morquio Diseases: The Role of PFN1 in Regulating Glycosaminoglycan Levels

Background: Mucopolysaccharidosis (MPS) is a class of hereditary metabolic diseases that demonstrate itself by accumulating incompletely degraded glycosaminoglycans (GAGs). MPS are classified according to the kind(s) of stored GAG(s) and specific genetic/enzymatic defects. Despite...

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Bibliographic Details
Main Authors: Karolina Wiśniewska, Magdalena Żabińska, Lidia Gaffke, Aneta Szulc, Beata M. Walter, Grzegorz Węgrzyn, Karolina Pierzynowska
Format: Article
Language:English
Published: IMR Press 2024-12-01
Series:Frontiers in Bioscience-Landmark
Subjects:
mucopolysaccharidoses
profilin-1
pfn1
glycosaminoglycans
sanfilippo disease
morquio disease
Online Access:https://www.imrpress.com/journal/FBL/29/12/10.31083/j.fbl2912415
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