A decision‐making tool for navigating extracellular vesicle research and product development
Abstract Due to their intercellular communication properties and involvement in a wide range of biological processes, extracellular vesicles (EVs) are increasingly being studied and exploited for different applications. Nevertheless, their complex nature and heterogeneity, as well as the challenges...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Journal of Extracellular Vesicles |
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| Online Access: | https://doi.org/10.1002/jev2.70021 |
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| author | Francesca Loria Sabrina Picciotto Giorgia Adamo Andrea Zendrini Samuele Raccosta Mauro Manno Paolo Bergese Giovanna L. Liguori Antonella Bongiovanni Nataša Zarovni |
| author_facet | Francesca Loria Sabrina Picciotto Giorgia Adamo Andrea Zendrini Samuele Raccosta Mauro Manno Paolo Bergese Giovanna L. Liguori Antonella Bongiovanni Nataša Zarovni |
| author_sort | Francesca Loria |
| collection | DOAJ |
| description | Abstract Due to their intercellular communication properties and involvement in a wide range of biological processes, extracellular vesicles (EVs) are increasingly being studied and exploited for different applications. Nevertheless, their complex nature and heterogeneity, as well as the challenges related to their purification and characterization procedures, require a cautious assessment of the qualitative and quantitative parameters that need to be monitored. This translates into a multitude of choices and putative solutions that any EV researcher must confront in both research and translational environments. In this respect, decision‐making tools may help assess various options, weigh pros and cons, and ultimately arrive at a thought‐out decision that considers both the best fit‐to‐source and fit‐to‐scope EV application(s). Here, we present a multi‐criteria EV decision‐making grid (EV‐DMG) as a novel, efficient, customizable, and easy‐to‐use tool to support EV research and innovation. By identifying and weighing key assessment criteria for comparing distinct EV‐based preparations and related processes, our EV‐DMG may assist any EV community member in making informed, traceable, and reproducible decisions regarding the management of EV sources or samples. Ultimately, this EV‐DMG may guide the adoption of the most suitable EV production and analytical pipelines for targeting a defined aim or application. |
| format | Article |
| id | doaj-art-a00f40b9add143b6aabb0ec562779f9f |
| institution | Kabale University |
| issn | 2001-3078 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Extracellular Vesicles |
| spelling | doaj-art-a00f40b9add143b6aabb0ec562779f9f2025-01-17T11:11:12ZengWileyJournal of Extracellular Vesicles2001-30782024-12-011312n/an/a10.1002/jev2.70021A decision‐making tool for navigating extracellular vesicle research and product developmentFrancesca Loria0Sabrina Picciotto1Giorgia Adamo2Andrea Zendrini3Samuele Raccosta4Mauro Manno5Paolo Bergese6Giovanna L. Liguori7Antonella Bongiovanni8Nataša Zarovni9HansaBioMed Life Sciences Ltd Tallinn EstoniaInstitute of Biomedical Research and Innovation (IRIB) National Research Council of Italy Palermo ItalyInstitute of Biomedical Research and Innovation (IRIB) National Research Council of Italy Palermo ItalyDepartment of Molecular and Translational Medicine University of Brescia Brescia ItalyInstitute of Biophysics National Research Council of Italy Palermo ItalyInstitute of Biophysics National Research Council of Italy Palermo ItalyDepartment of Molecular and Translational Medicine University of Brescia Brescia ItalyInstitute of Genetics and Biophysics (IGB) National Research Council of Italy Naples ItalyInstitute of Biomedical Research and Innovation (IRIB) National Research Council of Italy Palermo ItalyEVEBiofactory Srl Palermo ItalyAbstract Due to their intercellular communication properties and involvement in a wide range of biological processes, extracellular vesicles (EVs) are increasingly being studied and exploited for different applications. Nevertheless, their complex nature and heterogeneity, as well as the challenges related to their purification and characterization procedures, require a cautious assessment of the qualitative and quantitative parameters that need to be monitored. This translates into a multitude of choices and putative solutions that any EV researcher must confront in both research and translational environments. In this respect, decision‐making tools may help assess various options, weigh pros and cons, and ultimately arrive at a thought‐out decision that considers both the best fit‐to‐source and fit‐to‐scope EV application(s). Here, we present a multi‐criteria EV decision‐making grid (EV‐DMG) as a novel, efficient, customizable, and easy‐to‐use tool to support EV research and innovation. By identifying and weighing key assessment criteria for comparing distinct EV‐based preparations and related processes, our EV‐DMG may assist any EV community member in making informed, traceable, and reproducible decisions regarding the management of EV sources or samples. Ultimately, this EV‐DMG may guide the adoption of the most suitable EV production and analytical pipelines for targeting a defined aim or application.https://doi.org/10.1002/jev2.70021decision‐making toolsextracellular vesiclesmulti‐criteria decision‐makingproduct developmentquality controlresearch and development |
| spellingShingle | Francesca Loria Sabrina Picciotto Giorgia Adamo Andrea Zendrini Samuele Raccosta Mauro Manno Paolo Bergese Giovanna L. Liguori Antonella Bongiovanni Nataša Zarovni A decision‐making tool for navigating extracellular vesicle research and product development Journal of Extracellular Vesicles decision‐making tools extracellular vesicles multi‐criteria decision‐making product development quality control research and development |
| title | A decision‐making tool for navigating extracellular vesicle research and product development |
| title_full | A decision‐making tool for navigating extracellular vesicle research and product development |
| title_fullStr | A decision‐making tool for navigating extracellular vesicle research and product development |
| title_full_unstemmed | A decision‐making tool for navigating extracellular vesicle research and product development |
| title_short | A decision‐making tool for navigating extracellular vesicle research and product development |
| title_sort | decision making tool for navigating extracellular vesicle research and product development |
| topic | decision‐making tools extracellular vesicles multi‐criteria decision‐making product development quality control research and development |
| url | https://doi.org/10.1002/jev2.70021 |
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