The deer mouse (Peromyscus maniculatus bairdii) as a model organism to explore the naturalistic psychobiological mechanisms contributing to compulsive-like rigidity: A narrative overview of advances and opportunities
Deer mice (Peromyscus maniculatus bairdii), a wildtype species native to North America, have been investigated for their spontaneous compulsive-like behaviour. The repetitive and persistence nature of three unique compulsive-like phenotypes in deer mice, i.e., high stereotypy (HS), large nesting beh...
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Elsevier
2025-01-01
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| Series: | Comprehensive Psychiatry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0010440X24000968 |
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| author | Vasti Theron Chrstine Lochner Dan J. Stein Brian H Harvey De Wet Wolmarans |
| author_facet | Vasti Theron Chrstine Lochner Dan J. Stein Brian H Harvey De Wet Wolmarans |
| author_sort | Vasti Theron |
| collection | DOAJ |
| description | Deer mice (Peromyscus maniculatus bairdii), a wildtype species native to North America, have been investigated for their spontaneous compulsive-like behaviour. The repetitive and persistence nature of three unique compulsive-like phenotypes in deer mice, i.e., high stereotypy (HS), large nesting behaviour (LNB) and high marble burying (HMB), are characterized by behavioural and cognitive rigidity. In this narrative review, we summarize key advances in the model's application to study obsessive-compulsive disorder (OCD), emphasizing how it may be used to investigate neurobiological and neurocognitive aspects of rigidity. Indeed, deer mice provide the field with a unique naturalistic and spontaneous model system of behavioural and cognitive rigidity that is useful for investigating the psychobiological mechanisms that underpin a range of compulsive-like phenotypes. Throughout the review, we highlight new opportunities for future research. |
| format | Article |
| id | doaj-art-9fd0b0d0922a4d1b915a24f3f3f8af86 |
| institution | Kabale University |
| issn | 0010-440X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Comprehensive Psychiatry |
| spelling | doaj-art-9fd0b0d0922a4d1b915a24f3f3f8af862024-12-08T06:08:46ZengElsevierComprehensive Psychiatry0010-440X2025-01-01136152545The deer mouse (Peromyscus maniculatus bairdii) as a model organism to explore the naturalistic psychobiological mechanisms contributing to compulsive-like rigidity: A narrative overview of advances and opportunitiesVasti Theron0Chrstine Lochner1Dan J. Stein2Brian H Harvey3De Wet Wolmarans4Centre of Excellence for Pharmaceutical Sciences, Department of Pharmacology, North-West University, South AfricaSAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, South AfricaSAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Rondebosch 7700, South AfricaCentre of Excellence for Pharmaceutical Sciences, Department of Pharmacology, North-West University, South Africa; SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Rondebosch 7700, South Africa; The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, AustraliaCentre of Excellence for Pharmaceutical Sciences, Department of Pharmacology, North-West University, South Africa; Corresponding author at: Department of Pharmacology, Building G23, North-West University, 11 Hoffman Street, Potchefstroom, South Africa.Deer mice (Peromyscus maniculatus bairdii), a wildtype species native to North America, have been investigated for their spontaneous compulsive-like behaviour. The repetitive and persistence nature of three unique compulsive-like phenotypes in deer mice, i.e., high stereotypy (HS), large nesting behaviour (LNB) and high marble burying (HMB), are characterized by behavioural and cognitive rigidity. In this narrative review, we summarize key advances in the model's application to study obsessive-compulsive disorder (OCD), emphasizing how it may be used to investigate neurobiological and neurocognitive aspects of rigidity. Indeed, deer mice provide the field with a unique naturalistic and spontaneous model system of behavioural and cognitive rigidity that is useful for investigating the psychobiological mechanisms that underpin a range of compulsive-like phenotypes. Throughout the review, we highlight new opportunities for future research.http://www.sciencedirect.com/science/article/pii/S0010440X24000968Deer mouseRigidityNestMarble buryingStereotypyObsessive |
| spellingShingle | Vasti Theron Chrstine Lochner Dan J. Stein Brian H Harvey De Wet Wolmarans The deer mouse (Peromyscus maniculatus bairdii) as a model organism to explore the naturalistic psychobiological mechanisms contributing to compulsive-like rigidity: A narrative overview of advances and opportunities Comprehensive Psychiatry Deer mouse Rigidity Nest Marble burying Stereotypy Obsessive |
| title | The deer mouse (Peromyscus maniculatus bairdii) as a model organism to explore the naturalistic psychobiological mechanisms contributing to compulsive-like rigidity: A narrative overview of advances and opportunities |
| title_full | The deer mouse (Peromyscus maniculatus bairdii) as a model organism to explore the naturalistic psychobiological mechanisms contributing to compulsive-like rigidity: A narrative overview of advances and opportunities |
| title_fullStr | The deer mouse (Peromyscus maniculatus bairdii) as a model organism to explore the naturalistic psychobiological mechanisms contributing to compulsive-like rigidity: A narrative overview of advances and opportunities |
| title_full_unstemmed | The deer mouse (Peromyscus maniculatus bairdii) as a model organism to explore the naturalistic psychobiological mechanisms contributing to compulsive-like rigidity: A narrative overview of advances and opportunities |
| title_short | The deer mouse (Peromyscus maniculatus bairdii) as a model organism to explore the naturalistic psychobiological mechanisms contributing to compulsive-like rigidity: A narrative overview of advances and opportunities |
| title_sort | deer mouse peromyscus maniculatus bairdii as a model organism to explore the naturalistic psychobiological mechanisms contributing to compulsive like rigidity a narrative overview of advances and opportunities |
| topic | Deer mouse Rigidity Nest Marble burying Stereotypy Obsessive |
| url | http://www.sciencedirect.com/science/article/pii/S0010440X24000968 |
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