Lipids and carotenoids may influence the neuropathology of Alzheimer's disease: A meta-analysis
Introduction: Various studies have supported the key role of altered levels of lipids and carotenoids in the pathogenesis of Alzheimer's disease (AD), as they have the potential to maintain neuronal and tissue homeostasis. Methods: We conducted literature search on the PubMed and Google Scholar...
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Elsevier
2024-12-01
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| Series: | Archives of Gerontology and Geriatrics Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950307824000699 |
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| author | Aman Tiwari Avtar Singh Gautam Ekta Swarnamayee Panda Rakesh Kumar Singh |
| author_facet | Aman Tiwari Avtar Singh Gautam Ekta Swarnamayee Panda Rakesh Kumar Singh |
| author_sort | Aman Tiwari |
| collection | DOAJ |
| description | Introduction: Various studies have supported the key role of altered levels of lipids and carotenoids in the pathogenesis of Alzheimer's disease (AD), as they have the potential to maintain neuronal and tissue homeostasis. Methods: We conducted literature search on the PubMed and Google Scholar databases from the inception until December 2023. Two independent authors (AT and ASG) performed the data extraction, study selection, and quality assessment. The review outcomes were the level of lipids and carotenoids in cerebrospinal fluid (CSF) and peripheral fluids (serum and plasma) of patients with AD. The Cochrane Collaboration's Review Manager 5.4 was used to conduct this meta-analysis. Results: 107 studies showing levels of lipids and carotenoids in CSF and peripheral fluid of participants were included for the analysis. Peripheral cholesterol (p = 0.04) and CSF cholesterol (p = 0.04), CSF 24S-hydroxycholesterol (p = 0.01), CSF 27-hydroxycholesterol (p = 0.005), peripheral low-density lipoprotein (p = 0.02), and peripheral triglyceride (p = 0.03) from the lipid category were found to be associated with AD patients. However, the levels of carotenoids like α-carotene (p = 0.0006), β-carotene (p < 0.0001), β-cryptoxanthin (p = 0.0001), lutein (p < 0.0001), lycopene (p < 0.0001), and zeaxanthin (p < 0.0001) were decreased in AD patients compared to control. Conclusion: We concluded that the level of lipids and carotenoids are clearly associated with AD pathology. These altered level of lipids and carotenoids may provide an insight into the early diagnosis of the disease. |
| format | Article |
| id | doaj-art-9fc9e24a5cff44c88804112c9aeaa2aa |
| institution | Kabale University |
| issn | 2950-3078 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Archives of Gerontology and Geriatrics Plus |
| spelling | doaj-art-9fc9e24a5cff44c88804112c9aeaa2aa2024-12-13T11:09:42ZengElsevierArchives of Gerontology and Geriatrics Plus2950-30782024-12-0114100072Lipids and carotenoids may influence the neuropathology of Alzheimer's disease: A meta-analysisAman Tiwari0Avtar Singh Gautam1Ekta Swarnamayee Panda2Rakesh Kumar Singh3Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli, Transit campus, Bijnour-sisendi road, Sarojini nagar, Lucknow 226002, Uttar Pradesh, IndiaDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli, Transit campus, Bijnour-sisendi road, Sarojini nagar, Lucknow 226002, Uttar Pradesh, IndiaDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli, Transit campus, Bijnour-sisendi road, Sarojini nagar, Lucknow 226002, Uttar Pradesh, IndiaCorresponding author.; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli, Transit campus, Bijnour-sisendi road, Sarojini nagar, Lucknow 226002, Uttar Pradesh, IndiaIntroduction: Various studies have supported the key role of altered levels of lipids and carotenoids in the pathogenesis of Alzheimer's disease (AD), as they have the potential to maintain neuronal and tissue homeostasis. Methods: We conducted literature search on the PubMed and Google Scholar databases from the inception until December 2023. Two independent authors (AT and ASG) performed the data extraction, study selection, and quality assessment. The review outcomes were the level of lipids and carotenoids in cerebrospinal fluid (CSF) and peripheral fluids (serum and plasma) of patients with AD. The Cochrane Collaboration's Review Manager 5.4 was used to conduct this meta-analysis. Results: 107 studies showing levels of lipids and carotenoids in CSF and peripheral fluid of participants were included for the analysis. Peripheral cholesterol (p = 0.04) and CSF cholesterol (p = 0.04), CSF 24S-hydroxycholesterol (p = 0.01), CSF 27-hydroxycholesterol (p = 0.005), peripheral low-density lipoprotein (p = 0.02), and peripheral triglyceride (p = 0.03) from the lipid category were found to be associated with AD patients. However, the levels of carotenoids like α-carotene (p = 0.0006), β-carotene (p < 0.0001), β-cryptoxanthin (p = 0.0001), lutein (p < 0.0001), lycopene (p < 0.0001), and zeaxanthin (p < 0.0001) were decreased in AD patients compared to control. Conclusion: We concluded that the level of lipids and carotenoids are clearly associated with AD pathology. These altered level of lipids and carotenoids may provide an insight into the early diagnosis of the disease.http://www.sciencedirect.com/science/article/pii/S2950307824000699LipidsCarotenoidsAlzheimer's diseaseNeuroinflammationBiomarkersNeurodegenerative disease |
| spellingShingle | Aman Tiwari Avtar Singh Gautam Ekta Swarnamayee Panda Rakesh Kumar Singh Lipids and carotenoids may influence the neuropathology of Alzheimer's disease: A meta-analysis Archives of Gerontology and Geriatrics Plus Lipids Carotenoids Alzheimer's disease Neuroinflammation Biomarkers Neurodegenerative disease |
| title | Lipids and carotenoids may influence the neuropathology of Alzheimer's disease: A meta-analysis |
| title_full | Lipids and carotenoids may influence the neuropathology of Alzheimer's disease: A meta-analysis |
| title_fullStr | Lipids and carotenoids may influence the neuropathology of Alzheimer's disease: A meta-analysis |
| title_full_unstemmed | Lipids and carotenoids may influence the neuropathology of Alzheimer's disease: A meta-analysis |
| title_short | Lipids and carotenoids may influence the neuropathology of Alzheimer's disease: A meta-analysis |
| title_sort | lipids and carotenoids may influence the neuropathology of alzheimer s disease a meta analysis |
| topic | Lipids Carotenoids Alzheimer's disease Neuroinflammation Biomarkers Neurodegenerative disease |
| url | http://www.sciencedirect.com/science/article/pii/S2950307824000699 |
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