A Case of Type 2 Amiodarone-Induced Thyrotoxicosis That Underwent Total Thyroidectomy under High-Dose Steroid Administration

Amiodarone is used commonly and effectively in the treatment of arrhythmia; however, it may cause thyrotoxicosis categorized into two types: iodine-induced hyperthyroidism (type 1 amiodarone-induced thyrotoxicosis (AIT)) and destructive thyroiditis (type 2 AIT). We experienced a case of type 2 AIT,...

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Main Authors: Koshi Hashimoto, Masaki Ota, Tadanobu Irie, Daisuke Takata, Tadashi Nakajima, Yoshiaki Kaneko, Yuko Tanaka, Shunichi Matsumoto, Yasuyo Nakajima, Masahiko Kurabayashi, Tetsunari Oyama, Izumi Takeyoshi, Masatomo Mori, Masanobu Yamada
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Case Reports in Endocrinology
Online Access:http://dx.doi.org/10.1155/2015/416145
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Summary:Amiodarone is used commonly and effectively in the treatment of arrhythmia; however, it may cause thyrotoxicosis categorized into two types: iodine-induced hyperthyroidism (type 1 amiodarone-induced thyrotoxicosis (AIT)) and destructive thyroiditis (type 2 AIT). We experienced a case of type 2 AIT, in which high-dose steroid was administered intravenously, and we finally decided to perform total thyroidectomy, resulting in a complete cure of the AIT. Even though steroid had been administered to the patient (maximum 80 mg of prednisolone), the operation was performed safely and no acute adrenal crisis as steroid withdrawal syndrome was found after the operation. Few cases of type 2 AIT that underwent total thyroidectomy with high-dose steroid administration have been reported. The current case suggests that total thyroidectomy should be taken into consideration for patients with AIT who cannot be controlled by medical treatment and even in those under high-dose steroid administration.
ISSN:2090-6501
2090-651X