Strongyloides stercoralis combined with concurrent multiple pathogens infections in an immunosuppressed patient: a case report
BackgroundStrongyloides stercoralis is an opportunistic pathogenic parasite. Most individuals with normal immune function may not exhibit significant symptoms, and the signs are atypical, which can easily lead to missed diagnoses and delayed treatment. People with underlying diseases and weakened im...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1519065/full |
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| author | Jingchun Fang Jingchun Fang Huimin Fang Huimin Fang Penghao Guo Yaqin Peng Peisong Chen |
| author_facet | Jingchun Fang Jingchun Fang Huimin Fang Huimin Fang Penghao Guo Yaqin Peng Peisong Chen |
| author_sort | Jingchun Fang |
| collection | DOAJ |
| description | BackgroundStrongyloides stercoralis is an opportunistic pathogenic parasite. Most individuals with normal immune function may not exhibit significant symptoms, and the signs are atypical, which can easily lead to missed diagnoses and delayed treatment. People with underlying diseases and weakened immunity are prone to develop severe conditions after infection with Strongyloides stercoralis.Case presentationWe report an immunocompromised patient in whom the pathogen was initially not detectable using traditional parasitic detection techniques. However, Strongyloides stercoralis was identified in both the alveolar lavage fluid and blood through metagenomic next-generation sequencing. Subsequently, Strongyloides stercoralis was detected in the alveolar lavage fluid after multiple rounds of testing using traditional microscopic examination techniques. Based on the mNGS results and other examination findings, the patient was diagnosed with Strongyloides stercoralis in combination with concurrent multiple pathogens infections. After the combined drug therapy of Meropenem, Vancomycin, and Albendazole, the patient’s condition was gradually brought under control.ConclusionThis case demonstrates the advantage of integrating traditional detection methods with metagenomics next-generation sequencing technology in the etiological diagnosis of immunocompromised individuals. It is conducive to clarifying the etiological diagnosis of patients and thereby facilitating the timely initiation of corresponding treatments. |
| format | Article |
| id | doaj-art-9fb08ba441a64520936ee9561713bed1 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-9fb08ba441a64520936ee9561713bed12025-01-08T18:12:26ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15190651519065Strongyloides stercoralis combined with concurrent multiple pathogens infections in an immunosuppressed patient: a case reportJingchun Fang0Jingchun Fang1Huimin Fang2Huimin Fang3Penghao Guo4Yaqin Peng5Peisong ChenDepartment of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Laboratory Medicine, Nansha Division, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Laboratory Medicine, Nansha Division, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaBackgroundStrongyloides stercoralis is an opportunistic pathogenic parasite. Most individuals with normal immune function may not exhibit significant symptoms, and the signs are atypical, which can easily lead to missed diagnoses and delayed treatment. People with underlying diseases and weakened immunity are prone to develop severe conditions after infection with Strongyloides stercoralis.Case presentationWe report an immunocompromised patient in whom the pathogen was initially not detectable using traditional parasitic detection techniques. However, Strongyloides stercoralis was identified in both the alveolar lavage fluid and blood through metagenomic next-generation sequencing. Subsequently, Strongyloides stercoralis was detected in the alveolar lavage fluid after multiple rounds of testing using traditional microscopic examination techniques. Based on the mNGS results and other examination findings, the patient was diagnosed with Strongyloides stercoralis in combination with concurrent multiple pathogens infections. After the combined drug therapy of Meropenem, Vancomycin, and Albendazole, the patient’s condition was gradually brought under control.ConclusionThis case demonstrates the advantage of integrating traditional detection methods with metagenomics next-generation sequencing technology in the etiological diagnosis of immunocompromised individuals. It is conducive to clarifying the etiological diagnosis of patients and thereby facilitating the timely initiation of corresponding treatments.https://www.frontiersin.org/articles/10.3389/fmed.2024.1519065/fullStrongyloides stercoralispneumoniametagenomic next-generation sequencingco-infectionimmunocompromisation |
| spellingShingle | Jingchun Fang Jingchun Fang Huimin Fang Huimin Fang Penghao Guo Yaqin Peng Peisong Chen Strongyloides stercoralis combined with concurrent multiple pathogens infections in an immunosuppressed patient: a case report Frontiers in Medicine Strongyloides stercoralis pneumonia metagenomic next-generation sequencing co-infection immunocompromisation |
| title | Strongyloides stercoralis combined with concurrent multiple pathogens infections in an immunosuppressed patient: a case report |
| title_full | Strongyloides stercoralis combined with concurrent multiple pathogens infections in an immunosuppressed patient: a case report |
| title_fullStr | Strongyloides stercoralis combined with concurrent multiple pathogens infections in an immunosuppressed patient: a case report |
| title_full_unstemmed | Strongyloides stercoralis combined with concurrent multiple pathogens infections in an immunosuppressed patient: a case report |
| title_short | Strongyloides stercoralis combined with concurrent multiple pathogens infections in an immunosuppressed patient: a case report |
| title_sort | strongyloides stercoralis combined with concurrent multiple pathogens infections in an immunosuppressed patient a case report |
| topic | Strongyloides stercoralis pneumonia metagenomic next-generation sequencing co-infection immunocompromisation |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1519065/full |
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