Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma

Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma

Recently, it was revealed that the high-risk, poor-prognosis downregulation of GABA type A receptor-associated protein (GABARAP) causes a defect in both autophagy and surface exposure of calreticulin (CALR) in multiple myeloma (MM) cells responding to bortezomib. Hence, GABARAP-defective MM cells fa...

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Bibliographic Details
Main Authors: Liwei Zhao, Zhe Shen, Guido Kroemer, Oliver Kepp
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Immunotherapy
danger associated molecular pattern
autophagy
phagocytosis
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2360275
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