EIF4A3 enhances the viability, invasion and osteogenic differentiation of BMSCs via the USP53/SMAD5 pathway

EIF4A3 enhances the viability, invasion and osteogenic differentiation of BMSCs via the USP53/SMAD5 pathway

Abstract SMAD5 has been demonstrated to promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through the circ_0001825/miR-1270/SMAD5 axis or KCNQ1OT1/miR-320a/SMAD5 axis. Therefore, SMAD5 may be a key regulator of BMSCs osteogenic differentiation, and its more related mol...

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Bibliographic Details
Main Authors: Gang Cheng, Xiaoling Yang, Yongtao Tang, Changjun Wu, Zulin Tang, Siqi Wei
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
BMSCs
Osteogenic differentiation
SMAD5
USP53
EIF4A3
Online Access:https://doi.org/10.1038/s41598-025-86048-1
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