Exosome-based cell therapy for diabetic foot ulcers: Present and prospect
Diabetic foot ulcers (DFUs) represent a serious complication of diabetes with high incidence, requiring intensive treatment, prolonged hospitalization, and high costs. It poses a severe threat to the patient's life, resulting in substantial burdens on patient and healthcare system. However, the...
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| Language: | English |
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Elsevier
2024-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024152826 |
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| author | Zhou Yang Mengling Yang Shunli Rui Wei Hao Xiaohua Wu Lian Guo David G. Armstrong Cheng Yang Wuquan Deng |
| author_facet | Zhou Yang Mengling Yang Shunli Rui Wei Hao Xiaohua Wu Lian Guo David G. Armstrong Cheng Yang Wuquan Deng |
| author_sort | Zhou Yang |
| collection | DOAJ |
| description | Diabetic foot ulcers (DFUs) represent a serious complication of diabetes with high incidence, requiring intensive treatment, prolonged hospitalization, and high costs. It poses a severe threat to the patient's life, resulting in substantial burdens on patient and healthcare system. However, the therapy of DFUs remains challenging. Therefore, exploring cell-free therapies for DFUs is both critical and urgent. Exosomes, as crucial mediators of intercellular communication, have been demonstrated potentially effective in anti-inflammation, angiogenesis, cell proliferation and migration, and collagen deposition. These functions have been proven beneficial in all stages of diabetic wound healing. This review aims to summarize the role and mechanisms of exosomes from diverse cellular sources in diabetic wound healing research. In addition, we elaborate on the challenges for clinical application, discuss the advantages of membrane vesicles as exosome mimics in wound healing, and present the therapeutic potential of exosomes and their mimetic vesicles for future clinical applications. |
| format | Article |
| id | doaj-art-9f6f28d7be1a4d27aedf60f00ed33c58 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-9f6f28d7be1a4d27aedf60f00ed33c582024-11-12T05:20:11ZengElsevierHeliyon2405-84402024-10-011020e39251Exosome-based cell therapy for diabetic foot ulcers: Present and prospectZhou Yang0Mengling Yang1Shunli Rui2Wei Hao3Xiaohua Wu4Lian Guo5David G. Armstrong6Cheng Yang7Wuquan Deng8Department of Endocrinology and Metabolism, School of Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, 400014, ChinaDepartment of Endocrinology and Metabolism, School of Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, 400014, ChinaDepartment of Endocrinology and Metabolism, School of Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, 400014, ChinaDepartment of Endocrinology and Metabolism, School of Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, 400014, ChinaDepartment of Endocrinology and Metabolism, School of Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, 400014, ChinaDepartment of Endocrinology, School of Medicine, Chongqing University Three Gorges Central Hospital, Chongqing, 404000, ChinaDepartment of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USADepartment of Endocrinology and Metabolism, School of Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, 400014, China; Corresponding author.Department of Endocrinology and Metabolism, School of Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, 400014, China; Corresponding author.Diabetic foot ulcers (DFUs) represent a serious complication of diabetes with high incidence, requiring intensive treatment, prolonged hospitalization, and high costs. It poses a severe threat to the patient's life, resulting in substantial burdens on patient and healthcare system. However, the therapy of DFUs remains challenging. Therefore, exploring cell-free therapies for DFUs is both critical and urgent. Exosomes, as crucial mediators of intercellular communication, have been demonstrated potentially effective in anti-inflammation, angiogenesis, cell proliferation and migration, and collagen deposition. These functions have been proven beneficial in all stages of diabetic wound healing. This review aims to summarize the role and mechanisms of exosomes from diverse cellular sources in diabetic wound healing research. In addition, we elaborate on the challenges for clinical application, discuss the advantages of membrane vesicles as exosome mimics in wound healing, and present the therapeutic potential of exosomes and their mimetic vesicles for future clinical applications.http://www.sciencedirect.com/science/article/pii/S2405844024152826Diabetic foot ulcersWound healingExosomesMembrane vesiclesRegenerative medicine |
| spellingShingle | Zhou Yang Mengling Yang Shunli Rui Wei Hao Xiaohua Wu Lian Guo David G. Armstrong Cheng Yang Wuquan Deng Exosome-based cell therapy for diabetic foot ulcers: Present and prospect Heliyon Diabetic foot ulcers Wound healing Exosomes Membrane vesicles Regenerative medicine |
| title | Exosome-based cell therapy for diabetic foot ulcers: Present and prospect |
| title_full | Exosome-based cell therapy for diabetic foot ulcers: Present and prospect |
| title_fullStr | Exosome-based cell therapy for diabetic foot ulcers: Present and prospect |
| title_full_unstemmed | Exosome-based cell therapy for diabetic foot ulcers: Present and prospect |
| title_short | Exosome-based cell therapy for diabetic foot ulcers: Present and prospect |
| title_sort | exosome based cell therapy for diabetic foot ulcers present and prospect |
| topic | Diabetic foot ulcers Wound healing Exosomes Membrane vesicles Regenerative medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024152826 |
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