Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification?
The pathogenesis of membranous BCA recurrence remains unclear, with only a few cases reported. The current study focuses on a case that exhibits a high Ki-67 proliferative index, which raises questions about its impact on the prognosis and treatment plan. We have conducted a literature review to gai...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-09-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024004771 |
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| author | Dhinakaran Paranchodi Ashok Vikey Jaya Joshi Ramya Selvam Neha Choudhary |
| author_facet | Dhinakaran Paranchodi Ashok Vikey Jaya Joshi Ramya Selvam Neha Choudhary |
| author_sort | Dhinakaran Paranchodi |
| collection | DOAJ |
| description | The pathogenesis of membranous BCA recurrence remains unclear, with only a few cases reported. The current study focuses on a case that exhibits a high Ki-67 proliferative index, which raises questions about its impact on the prognosis and treatment plan. We have conducted a literature review to gain insight into the altered ki67 expression pattern in membranous BCA. We have also proposed a hypothesis that suggests recurrent membranous BCA cases with Ki67 levels between 5 % and 10 % signify an intermediate grade and warrant reclassification. More research is needed to confirm this hypothesis and understand the prognosis for this variant. |
| format | Article |
| id | doaj-art-9f664ca8595348b5a935e16cfc0dcd30 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-9f664ca8595348b5a935e16cfc0dcd302025-01-09T06:16:59ZengElsevierOral Oncology Reports2772-90602024-09-0111100631Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification?Dhinakaran Paranchodi0Ashok Vikey1Jaya Joshi2Ramya Selvam3Neha Choudhary4Dept of Oral & Maxillofacial Pathology & Oral Microbiology, Government College of Dentistry, Indore, IndiaDept of Oral & Maxillofacial Pathology & Oral Microbiology, Government College of Dentistry, Indore, IndiaDept of Oral & Maxillofacial Pathology & Oral Microbiology, Government College of Dentistry, Indore, IndiaCorresponding author.; Oral and Maxillofacial Pathologist and Oral Microbiologist, Dept of Dental Surgery, Lala Lajpat Rai Memorial Medical College, Meerut, IndiaDept of Oral & Maxillofacial Pathology & Oral Microbiology, Government College of Dentistry, Indore, IndiaThe pathogenesis of membranous BCA recurrence remains unclear, with only a few cases reported. The current study focuses on a case that exhibits a high Ki-67 proliferative index, which raises questions about its impact on the prognosis and treatment plan. We have conducted a literature review to gain insight into the altered ki67 expression pattern in membranous BCA. We have also proposed a hypothesis that suggests recurrent membranous BCA cases with Ki67 levels between 5 % and 10 % signify an intermediate grade and warrant reclassification. More research is needed to confirm this hypothesis and understand the prognosis for this variant.http://www.sciencedirect.com/science/article/pii/S2772906024004771Basal cell adenomaMembranous variantKi67and β -catenin |
| spellingShingle | Dhinakaran Paranchodi Ashok Vikey Jaya Joshi Ramya Selvam Neha Choudhary Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification? Oral Oncology Reports Basal cell adenoma Membranous variant Ki67 and β -catenin |
| title | Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification? |
| title_full | Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification? |
| title_fullStr | Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification? |
| title_full_unstemmed | Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification? |
| title_short | Does altered Ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification? |
| title_sort | does altered ki67 expression in recurrent membranous basal cell adenoma point toward the need for reclassification |
| topic | Basal cell adenoma Membranous variant Ki67 and β -catenin |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024004771 |
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