Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuli

Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuli

Abstract Inhibition of the mitochondrial oxidative phosphorylation (OXPHOS) system can lead to metabolic disorders and neurodegenerative diseases. In primary mitochondrial disorders, reactive astrocytes often accompany neuronal degeneration and may contribute to neurotoxic inflammatory cascades that...

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Bibliographic Details
Main Authors: Lena Wischhof, Amal John Mathew, Lorenzo Bonaguro, Marc Beyer, Dan Ehninger, Pierluigi Nicotera, Daniele Bano
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Reactive astrocytes
ATP-dependent chromatin remodeling SWI/SNF/BAF complex
Mitochondria
Online Access:https://doi.org/10.1038/s41598-024-78434-y
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