TOM5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumonia
Deficiency of TOM5, a mitochondrial protein, causes organizing pneumonia (OP) in mice. The clinical significance and mechanisms of TOM5 in the pathogenesis of OP remain elusive. We demonstrated that TOM5 was significantly increased in the lung tissues of OP patients, which was positively correlated...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Redox Report |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13510002.2024.2354625 |
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| author | Yan Qian Xiao Li Xinyu Li Xijie Zhang Qi Yuan Zhengxia Wang Mingshun Zhang Mao Huang Ningfei Ji |
| author_facet | Yan Qian Xiao Li Xinyu Li Xijie Zhang Qi Yuan Zhengxia Wang Mingshun Zhang Mao Huang Ningfei Ji |
| author_sort | Yan Qian |
| collection | DOAJ |
| description | Deficiency of TOM5, a mitochondrial protein, causes organizing pneumonia (OP) in mice. The clinical significance and mechanisms of TOM5 in the pathogenesis of OP remain elusive. We demonstrated that TOM5 was significantly increased in the lung tissues of OP patients, which was positively correlated with the collagen deposition. In a bleomycin-induced murine model of chronic OP, increased TOM5 was in line with lung fibrosis. In vitro, TOM5 regulated the mitochondrial membrane potential in alveolar epithelial cells. TOM5 reduced the proportion of early apoptotic cells and promoted cell proliferation. Our study shed light on the roles of TOM5 in OP. |
| format | Article |
| id | doaj-art-9f5a6e182b5d495eab3d81d7e3b4c3cb |
| institution | Kabale University |
| issn | 1351-0002 1743-2928 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Redox Report |
| spelling | doaj-art-9f5a6e182b5d495eab3d81d7e3b4c3cb2024-12-07T06:20:31ZengTaylor & Francis GroupRedox Report1351-00021743-29282024-12-0129110.1080/13510002.2024.2354625TOM5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumoniaYan Qian0Xiao Li1Xinyu Li2Xijie Zhang3Qi Yuan4Zhengxia Wang5Mingshun Zhang6Mao Huang7Ningfei Ji8Department of Respiratory and Critical Care Medicine, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaDepartment of Pathology, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, People’s Republic of ChinaNHC Key Laboratory of Antibody Technique, Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaNHC Key Laboratory of Antibody Technique, Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaDeficiency of TOM5, a mitochondrial protein, causes organizing pneumonia (OP) in mice. The clinical significance and mechanisms of TOM5 in the pathogenesis of OP remain elusive. We demonstrated that TOM5 was significantly increased in the lung tissues of OP patients, which was positively correlated with the collagen deposition. In a bleomycin-induced murine model of chronic OP, increased TOM5 was in line with lung fibrosis. In vitro, TOM5 regulated the mitochondrial membrane potential in alveolar epithelial cells. TOM5 reduced the proportion of early apoptotic cells and promoted cell proliferation. Our study shed light on the roles of TOM5 in OP.https://www.tandfonline.com/doi/10.1080/13510002.2024.2354625Organizing pneumoniaTOM5alveolar epithelial cellsmitochondrial membrane potential; bleomycin |
| spellingShingle | Yan Qian Xiao Li Xinyu Li Xijie Zhang Qi Yuan Zhengxia Wang Mingshun Zhang Mao Huang Ningfei Ji TOM5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumonia Redox Report Organizing pneumonia TOM5 alveolar epithelial cells mitochondrial membrane potential; bleomycin |
| title | TOM5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumonia |
| title_full | TOM5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumonia |
| title_fullStr | TOM5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumonia |
| title_full_unstemmed | TOM5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumonia |
| title_short | TOM5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumonia |
| title_sort | tom5 regulates the mitochondrial membrane potential of alveolar epithelial cells in organizing pneumonia |
| topic | Organizing pneumonia TOM5 alveolar epithelial cells mitochondrial membrane potential; bleomycin |
| url | https://www.tandfonline.com/doi/10.1080/13510002.2024.2354625 |
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