When a negative (charge) is not a positive: sialylation and its role in cancer mechanics and progression

When a negative (charge) is not a positive: sialylation and its role in cancer mechanics and progression

Sialic acids and sialoglycans are critical actors in cancer progression and metastasis. These terminal sugar residues on glycoproteins and glycolipids modulate key cellular processes such as immune evasion, cell adhesion, and migration. Aberrant sialylation is driven by overexpression of sialyltrans...

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Bibliographic Details
Main Authors: Issa Funsho Habeeb, Toheeb Eniola Alao, Daniella Delgado, Alexander Buffone
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Oncology
Subjects:
sialylation
cancer
glycocalyx
mechanobiology
metastasis
migration
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1487306/full
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