SF1-specific deletion of the energy sensor AMPKγ2 induces obesity

SF1-specific deletion of the energy sensor AMPKγ2 induces obesity

Objective: AMP-activated protein kinase (AMPK) is a heterotrimer complex consisting of a catalytic α subunit (α1, α2) with a serine/threonine kinase domain, and two regulatory subunits, β (β1, β2) and γ (γ1, γ2, γ3), encoded by different genes. In the hypothalamus, AMPK plays a crucial role in regul...

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Main Authors: Óscar Freire-Agulleiro, Ánxela Estévez-Salguero, Vitor Ferreira, Cassie Lynn Holleman, Julia García-Currás, Ismael González-García, Rubén Nogueiras, Manuel Tena-Sempere, Cristina García-Cáceres, Carlos Diéguez, Miguel López
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Molecular Metabolism
Subjects:
AMPK
BAT
Hypothalamus
Obesity
SF1
Thermogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824002229
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