Blood Microbiome Reveals the Impact of Lactobacillus on the Efficacy of Immunotherapy in Gastrointestinal Cancer

Blood Microbiome Reveals the Impact of Lactobacillus on the Efficacy of Immunotherapy in Gastrointestinal Cancer

Abstract Immunotherapy has revolutionized the treatment of gastrointestinal (GI) cancers, but reliable biomarkers for predicting treatment efficacy remain limited. In this study, we explored the potential of blood microbiome and specific microbial taxa as novel biomarkers for predicting the efficacy...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ya‐Shang Zheng, Wu‐Hao Lin, Jun‐Quan Chen, Xiao‐Li Wei, Jia‐Qian Huang, Yu‐Hong Xu, Meng Yang, Qi‐Hua Zhang, Zhi‐Jun Zuo, Zhao‐Ying Yang, Pan Zhang, Nga Ki HONG, Lu‐Xuan Liu, Zhao‐Lei Zeng, Rui‐Hua Xu, Hui‐Yan Luo
Format:	Article
Language:	English
Published:	Wiley 2025-08-01
Series:	MedComm
Subjects:	biomarker blood microbiome efficacy immunotherapy Lactobacillus
Online Access:	https://doi.org/10.1002/mco2.70316
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Nutritional status, immunonutrition, and gut microbiome: a coming of age for immunotherapy?
by: Elisa Mattavelli, et al.
Published: (2025-08-01)

Unveiling the Kadaknath Gut Microbiome: Early Growth Phase Spatiotemporal Diversity
by: Amruta Nair, et al.
Published: (2025-02-01)

Gut microbiome changes and cancer immunotherapy outcomes associated with dietary interventions: a systematic review of preclinical and clinical evidence
by: Csenge Somodi, et al.
Published: (2025-07-01)

Biological properties of lactobacillus
by: N. A. Glushanova
Published: (2003-12-01)

Lactobacillus plantarum liver abscess following ERCP: a case report and review
by: Wenjing Ren, et al.
Published: (2025-05-01)

Enhancing the quality of rice-based gluten-free bread using sourdoughs fermented with Lactobacillus fermentum and Lactobacillus plantarum
by: Sedigheh Seyedahmadi, et al.
Published: (2025-07-01)

Contribution of gut microbiome to pancreatic ductal adenocarcinoma development
by: D. V. Zaitsev, et al.
Published: (2025-05-01)

Native Lactobacillus and Bifidobacterium probiotics modulate autophagy genes and exert anti-inflammatory effect
by: Fatemeh Haririzadeh Jouriani, et al.
Published: (2025-07-01)

Gastrointestinal microbiome and gluten in celiac disease
by: Xingxing Wu, et al.
Published: (2021-01-01)

Comparative genomic analysis of bacteriocin genes in Lactobacillus crispatus strains
by: Giulia Santarelli, et al.
Published: (2025-07-01)

Dietary supplementation of Lactobacillus salivarius in suckling and weanling piglets modulates intestinal microbiota, morphology and improves growth performance
by: Elick Kinara, et al.
Published: (2025-07-01)

Lactobacillus rhamnosus MP108 alleviates ulcerative colitis in mice by enhancing the intestinal barrier, inhibiting inflammation, and modulating gut microbiota
by: Huizhen Li, et al.
Published: (2025-06-01)

Reply to “Exploring Bacteria‐Based Cancer Immunotherapy”—Comment on “Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics”
by: Eijiro Miyako
Published: (2025-08-01)

The effect of Lactobacillus acidophilus as a probiotic against Pseudomonas aeruginosa growth and biofilm formation
by: Shaimaa A. Elbadri, et al.
Published: (2019-08-01)

POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES
by: E. P. Kiseleva, et al.
Published: (2014-07-01)

Understanding the physiology of Lactobacillus plantarum at zero growth
by: Philippe Goffin, et al.
Published: (2010-09-01)

Effects of Lactobacillus reuteri and its combination with gluco-oligosaccharides on improving growth performance and intestinal health of broilers
by: Runzi Tang, et al.
Published: (2025-01-01)

EFFECTS OF DIFFERENT SUGARS, ALCOHOLS, ANTIOXIDANTS ON GOAT MILK TABLETS CONTAINING LACTOBACILLUS ACIDOPHILUS LA-5
by: DONGLIN MA, et al.
Published: (2018-09-01)

ANTI-PATHOGENIC Candida Spp. Activity DETERMINATION VIA Lactobacillus Spp. ISOLATION AND IDENTIFICATIONS USING CONVENTIONAL AND MOLECULAR METHODS
by: Hawraa F. H. AL-abedi, et al.
Published: (2020-11-01)

The Impact of Malted Grains on Human Intestinal Microbiota Composition in an In Vitro Model
by: Carlos Gómez-Gallego, et al.
Published: (2024-02-01)

Effect of β-glucan from Lactobacillus fermentum on serum lipid profile in rats
by: Maha Ahmed Najm, et al.
Published: (2024-12-01)

The gut microbiome in lung cancer: from pathogenesis to precision therapy
by: Miao Shi, et al.
Published: (2025-08-01)

ASSESSMENT OF THE BACTERIOCINOGENICITY OF INDIGEN LACTOBACILLUS ONTO CATTLE CARCASSES
by: Dagmara S. Bataeva, et al.
Published: (2018-07-01)

The effects of Lactobacillus reuteri on the inflammation and periodontal tissue repair in rats: A pilot study
by: Valdir Gouveia Garcia, et al.
Published: (2022-09-01)

The inhibitory Effect of Lactobacillus bulgaricus against some Pathogenic and Toxin Producing Fungi which isolated from soil
by: Luay B. Mustafa, et al.
Published: (2023-02-01)

Understanding the role of the gut microbiome in gastrointestinal cancer: A review
by: Duygu Ağagündüz, et al.
Published: (2023-01-01)

Efficacy and Safety of Neoadjuvant Immunotherapy plus Chemotherapy versus Neoadjuvant Chemotherapy in Non‐Small Cell Lung Cancer Treatment: A Mixed Method Meta‐Analysis Based on Global Randomized Controlled Trials
by: Shen Li, et al.
Published: (2025-06-01)

RS4 Type Resistant Starch Improves Type 2 Diabetes Mellitus in Mice by Interacting With Lactobacillus johnsonii
by: Tao Xu, et al.
Published: (2025-01-01)

Leveraging diverse liquid–liquid phase separation patterns to predict the prognosis and immunotherapy of pediatric acute myeloid leukemia
by: Min Kong, et al.
Published: (2025-08-01)

Gut microbiome in gastrointestinal neoplasms: from mechanisms to precision therapeutic strategies
by: Jiaqian Song, et al.
Published: (2025-07-01)

The Role of Lactobacillus reuteri DSMZ17648 for Helicobacter pylori eradication therapy (Review of literature and advisory council resolution, February 28, 2018)
by: V. T. Ivashkin, et al.
Published: (2018-08-01)

Optimization of Solid-State Fermentation with Lactobacillus brevis and Aspergillus oryzae for Trypsin Inhibitor Degradation in Soybean Meal
by: You-ling GAO, et al.
Published: (2013-05-01)

Study on the cultivation of Lactobacillus using rice wine lees and protection capabilities during spray and freeze drying
by: Liya Tian, et al.
Published: (2025-07-01)

Antimicrobial potential and stability of Lactobacillus acidophilus-derived bacteriocins against multidrug-resistant common foodborne pathogens
by: Md Mahmudul Hasan, et al.
Published: (2025-06-01)

Lactobacillus reuteri DSM 17,938 ameliorates LPS-induced depression-like and anxiety-like behaviors by modulating gut microbiota and brain metabolic function
by: Xiaolong Mo, et al.
Published: (2025-08-01)

Exploring the Effects of Metabolites from Lactobacillus rhamnosus GM020 and Cyanidin-3-O-Glucoside on Differential Metabolites in the High-fat Diet Mice Liver Based on Metabolomics
by: Sihang WANG, et al.
Published: (2025-08-01)

The Respiratory Tract Microbiome and Human Health
by: Patricia Fernández deCórdoba‐Ansón, et al.
Published: (2025-05-01)

Anticancer and Antiproliferative Effects of Combined Treatment with 5-Fluorouracil and Probiotic Lactobacillus Strains against Colorectal Cancer Cells
by: Sanaz Salek, et al.
Published: (2024-12-01)

The Probiotic Effects of Lactobacillus brevis CD2 on Caries Related Variables of Dental Plaque Biofilm
by: Guglielmo Campus, et al.
Published: (2025-06-01)

Lactobacillus brevis YNH inhibits proliferation of HeLa cells and promotes their apoptosis by modulating the PI3K/AKT pathway
by: Liang He, et al.
Published: (2025-03-01)