Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mechanisms

Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mechanisms

Objectives: Carriers of PAM (peptidylglycine alpha-amidating monooxygenase) coding variant alleles have reduced insulinogenic index, higher risk of developing type 2 diabetes (T2D), and islets from heterozygous carriers of the PAM p.Asp563Gly variant display reduced insulin secretion. Exactly how gl...

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Main Authors: Yi-Chun Chen, Nils E. Bäck, Jenicia Zhen, Lena Xiong, Mitsuhiro Komba, Anna L. Gloyn, Patrick E. MacDonald, Richard E. Mains, Betty A. Eipper, C. Bruce Verchere
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Metabolism
Subjects:
Type 2 diabetes risk gene
Peptide hormone amidation
Insulin granules
Islet cilia
Islet amyloid polypeptide
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000304
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