Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor
Angiogenesis is a crucial step in the growth of cancer and its metastasis. It is regulated by several endogenous factors which may stimulate or inhibit the new blood vessel growth. Besides these endogenous factors, several exogenous factors including some natural compounds are known to modulate angi...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/843897 |
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| author | A. P. Athira A. Helen K. Saja P. Reddanna P. R. Sudhakaran |
| author_facet | A. P. Athira A. Helen K. Saja P. Reddanna P. R. Sudhakaran |
| author_sort | A. P. Athira |
| collection | DOAJ |
| description | Angiogenesis is a crucial step in the growth of cancer and its metastasis. It is regulated by several endogenous factors which may stimulate or inhibit the new blood vessel growth. Besides these endogenous factors, several exogenous factors including some natural compounds are known to modulate angiogenesis. Angiogenesis being a potential target for drugs against a number of pathological conditions, search for compounds from natural sources that can affect angiogenesis is of great interest. The objective of our present study was to understand the effect of chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., on angiogenesis. The model systems used were rat aortic rings and human umbilical vein endothelial cells. The results showed that chebulagic acid exerts an antiangiogenic effect. This was evidenced from decreased sprouting in rat aortic rings and decrease in biochemical markers in endothelial cells treated with chebulagic acid. It downregulated the production of CD31, E-selectin, and vascular endothelial growth factor in human umbilical vein endothelial cells in culture (HUVEC). Further studies to understand the molecular mechanism of action of chebulagic acid revealed that CA exerts its anti angiogenic effect by modulating VE cadherin-β catenin signalling in human umbilical vein endothelial cells. |
| format | Article |
| id | doaj-art-9eb3b8d228fb4d9abbe5dcdbc80e6a3d |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-9eb3b8d228fb4d9abbe5dcdbc80e6a3d2025-08-20T03:38:43ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322013-01-01201310.1155/2013/843897843897Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual InhibitorA. P. Athira0A. Helen1K. Saja2P. Reddanna3P. R. Sudhakaran4Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala 695581, IndiaDepartment of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala 695581, IndiaDepartment of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala 695581, IndiaNational Institute of Animal Biotechnology, University of Hyderabad Campus, Hyderabad 500046, IndiaDepartment of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala 695581, IndiaAngiogenesis is a crucial step in the growth of cancer and its metastasis. It is regulated by several endogenous factors which may stimulate or inhibit the new blood vessel growth. Besides these endogenous factors, several exogenous factors including some natural compounds are known to modulate angiogenesis. Angiogenesis being a potential target for drugs against a number of pathological conditions, search for compounds from natural sources that can affect angiogenesis is of great interest. The objective of our present study was to understand the effect of chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., on angiogenesis. The model systems used were rat aortic rings and human umbilical vein endothelial cells. The results showed that chebulagic acid exerts an antiangiogenic effect. This was evidenced from decreased sprouting in rat aortic rings and decrease in biochemical markers in endothelial cells treated with chebulagic acid. It downregulated the production of CD31, E-selectin, and vascular endothelial growth factor in human umbilical vein endothelial cells in culture (HUVEC). Further studies to understand the molecular mechanism of action of chebulagic acid revealed that CA exerts its anti angiogenic effect by modulating VE cadherin-β catenin signalling in human umbilical vein endothelial cells.http://dx.doi.org/10.1155/2013/843897 |
| spellingShingle | A. P. Athira A. Helen K. Saja P. Reddanna P. R. Sudhakaran Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor International Journal of Vascular Medicine |
| title | Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor |
| title_full | Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor |
| title_fullStr | Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor |
| title_full_unstemmed | Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor |
| title_short | Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor |
| title_sort | inhibition of angiogenesis in vitro by chebulagic acid a cox lox dual inhibitor |
| url | http://dx.doi.org/10.1155/2013/843897 |
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