Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain
Abstract Temporomandibular joint osteoarthritis (TMJ-OA) is a common disease often accompanied by pain, seriously affecting physical and mental health of patients. Abnormal innervation at the osteochondral junction has been considered as a predominant origin of arthralgia, while the specific mechani...
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Nature Publishing Group
2025-01-01
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| Series: | International Journal of Oral Science |
| Online Access: | https://doi.org/10.1038/s41368-024-00336-6 |
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| author | Zhangyu Ma Qianqian Wan Wenpin Qin Wen Qin Janfei Yan Yina Zhu Yuzhu Wang Yuxuan Ma Meichen Wan Xiaoxiao Han Haoyan Zhao Yuxuan Hou Franklin R. Tay Lina Niu Kai Jiao |
| author_facet | Zhangyu Ma Qianqian Wan Wenpin Qin Wen Qin Janfei Yan Yina Zhu Yuzhu Wang Yuxuan Ma Meichen Wan Xiaoxiao Han Haoyan Zhao Yuxuan Hou Franklin R. Tay Lina Niu Kai Jiao |
| author_sort | Zhangyu Ma |
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| description | Abstract Temporomandibular joint osteoarthritis (TMJ-OA) is a common disease often accompanied by pain, seriously affecting physical and mental health of patients. Abnormal innervation at the osteochondral junction has been considered as a predominant origin of arthralgia, while the specific mechanism mediating pain remains unclear. To investigate the underlying mechanism of TMJ-OA pain, an abnormal joint loading model was used to induce TMJ-OA pain. We found that during the development of TMJ-OA, the increased innervation of sympathetic nerve of subchondral bone precedes that of sensory nerves. Furthermore, these two types of nerves are spatially closely associated. Additionally, it was discovered that activation of sympathetic neural signals promotes osteoarthritic pain in mice, whereas blocking these signals effectively alleviates pain. In vitro experiments also confirmed that norepinephrine released by sympathetic neurons promotes the activation and axonal growth of sensory neurons. Moreover, we also discovered that through releasing norepinephrine, regional sympathetic nerves of subchondral bone were found to regulate growth and activation of local sensory nerves synergistically with other pain regulators. This study identified the role of regional sympathetic nerves in mediating pain in TMJ-OA. It sheds light on a new mechanism of abnormal innervation at the osteochondral junction and the regional crosstalk between peripheral nerves, providing a potential target for treating TMJ-OA pain. |
| format | Article |
| id | doaj-art-9eab3a9a87d54fd7b7f065d20750003f |
| institution | Kabale University |
| issn | 2049-3169 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | International Journal of Oral Science |
| spelling | doaj-art-9eab3a9a87d54fd7b7f065d20750003f2025-01-12T12:10:23ZengNature Publishing GroupInternational Journal of Oral Science2049-31692025-01-0117111610.1038/s41368-024-00336-6Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic painZhangyu Ma0Qianqian Wan1Wenpin Qin2Wen Qin3Janfei Yan4Yina Zhu5Yuzhu Wang6Yuxuan Ma7Meichen Wan8Xiaoxiao Han9Haoyan Zhao10Yuxuan Hou11Franklin R. Tay12Lina Niu13Kai Jiao14Department of Stomatology, Tangdu Hospital & State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical UniversityDepartment of Stomatology, Tangdu Hospital & State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical UniversityDepartment of Stomatology, Tangdu Hospital & State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical UniversityDepartment of Stomatology, Tangdu Hospital & State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical UniversityDepartment of Stomatology, Tangdu Hospital & State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical UniversityDepartment of Stomatology, Tangdu Hospital & State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical UniversityThe Graduate School, Augusta UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical UniversityDepartment of Stomatology, Tangdu Hospital & State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical UniversityAbstract Temporomandibular joint osteoarthritis (TMJ-OA) is a common disease often accompanied by pain, seriously affecting physical and mental health of patients. Abnormal innervation at the osteochondral junction has been considered as a predominant origin of arthralgia, while the specific mechanism mediating pain remains unclear. To investigate the underlying mechanism of TMJ-OA pain, an abnormal joint loading model was used to induce TMJ-OA pain. We found that during the development of TMJ-OA, the increased innervation of sympathetic nerve of subchondral bone precedes that of sensory nerves. Furthermore, these two types of nerves are spatially closely associated. Additionally, it was discovered that activation of sympathetic neural signals promotes osteoarthritic pain in mice, whereas blocking these signals effectively alleviates pain. In vitro experiments also confirmed that norepinephrine released by sympathetic neurons promotes the activation and axonal growth of sensory neurons. Moreover, we also discovered that through releasing norepinephrine, regional sympathetic nerves of subchondral bone were found to regulate growth and activation of local sensory nerves synergistically with other pain regulators. This study identified the role of regional sympathetic nerves in mediating pain in TMJ-OA. It sheds light on a new mechanism of abnormal innervation at the osteochondral junction and the regional crosstalk between peripheral nerves, providing a potential target for treating TMJ-OA pain.https://doi.org/10.1038/s41368-024-00336-6 |
| spellingShingle | Zhangyu Ma Qianqian Wan Wenpin Qin Wen Qin Janfei Yan Yina Zhu Yuzhu Wang Yuxuan Ma Meichen Wan Xiaoxiao Han Haoyan Zhao Yuxuan Hou Franklin R. Tay Lina Niu Kai Jiao Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain International Journal of Oral Science |
| title | Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain |
| title_full | Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain |
| title_fullStr | Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain |
| title_full_unstemmed | Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain |
| title_short | Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain |
| title_sort | effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain |
| url | https://doi.org/10.1038/s41368-024-00336-6 |
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