IMMUNOLOGICAL MECHANISMS OF THERAPEUTIC EFFICACY OF OXIDIZED DEXTRAN IN SPERMATOGENESIS DISORDERS OF INFECTIOUS AND INFLAMMATORY GENESIS
AbstractThe article summarizes experimental and clinical data on the immunological properties of oxidized dextran. The main emphasis is on the pathophysiological mechanism of action of oxidized dextran, in particular on its ability to selectively activate tissue macrophages, including testicular mac...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2019-08-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/3137 |
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| Summary: | AbstractThe article summarizes experimental and clinical data on the immunological properties of oxidized dextran. The main emphasis is on the pathophysiological mechanism of action of oxidized dextran, in particular on its ability to selectively activate tissue macrophages, including testicular macrophages, which are directly involved in spermatogenesis. In the experimental part of the work on the model of spermatogenesis disorders in rats induced by the introduction of Escherichia coli endotoxin, it was shown that oxidized dextran significantly reduces pathomorphological changes in the testes. At the same time, such an effect is associated with the activation of tissue macrophages and the release of corresponding cytokines, which are aimed at stopping the inflammatory process and normalizing microcirculatory hemodynamics. The presented experimental data correlate with the data on the high clinical efficacy of oxidized dextran in spermatogenesis disorders and male infertility. In the clinical part of the work on the effect of rectal administration of oxidized dextran in patients with severe spermatogenesis disorders, it was shown that oxidized dextran significantly increases the volume of ejaculate, the concentration of spermatozoa in the ejaculate, and the total number of spermatozoa. The authors link the data of experimental and clinical studies within the framework of a single concept of tissue macrophage activation and the ability of macrophages to change their phenotype depending on the microenvironment and the characteristics of the infectious and inflammatory process. This approach is also confirmed by clinical data on the effect of macrophage phenotypes on drug resistance and the severity of intracellular infections, in particular tuberculosis. The analysis of experimental and clinical data allows the authors to propose a theoretical model of the mechanism of therapeutic effectiveness of oxidized dextran in intracellular infections. The experimental and clinical data presented by the authors allow us to consider oxidized dextran as a very effective means for the treatment of intracellular infections, including urogenital infections causing male infertility. |
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| ISSN: | 1563-0625 2313-741X |