SPTLC3 regulates plasma membrane sphingolipid composition to facilitate hepatic gluconeogenesis

SPTLC3 regulates plasma membrane sphingolipid composition to facilitate hepatic gluconeogenesis

Summary: SPTLC3, an inducible subunit of the serine palmitoyltransferase (SPT) complex, causes production of alternative sphingoid bases, including a 16-carbon dihydrosphingosine, whose biological function is only beginning to emerge. High-fat feeding induced SPTLC3 in the liver, prompting us to pro...

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Bibliographic Details
Main Authors:	David Montefusco, Maryam Jamil, Daniel Canals, Siri Saligrama, Yang Yue, Jeremy Allegood, L. Ashley Cowart
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Series:	Cell Reports
Subjects:	CP: Metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124724014050
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