The effect of Polymorphism of the MDR1 (ABCB1) Gene on the Risk of Hepatotoxic Reactions in Patients with Pulmonary Tuberculosis
Currently, a decrease is seen in the effectiveness of treatment in patients with tuberculosis due to the appearance of adverse reactions to anti-tuberculosis drugs. Hepatotoxic reactions play an especially important role in anti-tuberculosis therapy, and phthisiologists often have to deal with the c...
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LLC "Publishing House OKI"
2023-12-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/1064 |
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| author | М. А. Alymenko R. Sh. Valiev N. R. Valiev I. N. Tragira А. V. Polonikov N. Р. Balobanova A. V. Batishchev V. М. Kolomiets G. S. Mal S. N. Volkova V. V. Kozlov E. I. Suslikova E. V. Popova |
| author_facet | М. А. Alymenko R. Sh. Valiev N. R. Valiev I. N. Tragira А. V. Polonikov N. Р. Balobanova A. V. Batishchev V. М. Kolomiets G. S. Mal S. N. Volkova V. V. Kozlov E. I. Suslikova E. V. Popova |
| author_sort | М. А. Alymenko |
| collection | DOAJ |
| description | Currently, a decrease is seen in the effectiveness of treatment in patients with tuberculosis due to the appearance of adverse reactions to anti-tuberculosis drugs. Hepatotoxic reactions play an especially important role in anti-tuberculosis therapy, and phthisiologists often have to deal with the cancellation of a number of anti-tuberculosis drugs. The aim of the study was to investigate the relationship of polymorphic gene variants of xenobiotic biotransformation metabolizing enzymes (NAT2 (590G>A (rs1799930), CYP2E1 (9896C>G (rs2070676), ABCB1 (3435T>C (rs1045642), GSTM1 (E/D), GSTT1 (E/D) with the risk of hepatotoxic reactions in patients with pulmonary tuberculosis. Material and methods. The logistic regression analysis method was used to predict the probability of hepatoxic reactions during specific anti-tuberculosis therapy. Results: 1 statistically significant model was obtained, which reflects the association with hepatotoxic reactions to anti-tuberculosis drugs of the TS genotypes or the TS gene (T allele) ABSV1 (rs1045642). Conclusion. Pharmacogenetic testing used in the study allows us to identify risk groups of patients with pulmonary tuberculosis according to the likelihood of hepatotoxic reactions, which may provide an individualized approach to the treatment of these patients in the future. |
| format | Article |
| id | doaj-art-9e6f4aaf6e4a48ea96abf6242c4a60d1 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2023-12-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-9e6f4aaf6e4a48ea96abf6242c4a60d12025-08-20T03:59:08ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902023-12-01687-8626910.37489/0235-2990-2023-68-7-8-62-69980The effect of Polymorphism of the MDR1 (ABCB1) Gene on the Risk of Hepatotoxic Reactions in Patients with Pulmonary TuberculosisМ. А. Alymenko0R. Sh. Valiev1N. R. Valiev2I. N. Tragira3А. V. Polonikov4N. Р. Balobanova5A. V. Batishchev6V. М. Kolomiets7G. S. Mal8S. N. Volkova9V. V. Kozlov10E. I. Suslikova11E. V. Popova12Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH; Center for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency; Moscow Financial and Industrial University «Synergy»Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOHKazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOHNational Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Ministry of Health of the Russian FederationKursk State Medical University of the Ministry of Health of the Russian FederationMoscow Financial and Industrial University «Synergy»Moscow Financial and Industrial University «Synergy»Kursk State Medical University of the Ministry of Health of the Russian FederationKursk State Medical University of the Ministry of Health of the Russian FederationKursk State Agricultural Academy named after IvanovaI. M. Sechenov First Moscow State Medical University (Sechenov University)Regional Clinical Tuberculosis DispensaryRegional Children's Clinical Hospital No. 2Currently, a decrease is seen in the effectiveness of treatment in patients with tuberculosis due to the appearance of adverse reactions to anti-tuberculosis drugs. Hepatotoxic reactions play an especially important role in anti-tuberculosis therapy, and phthisiologists often have to deal with the cancellation of a number of anti-tuberculosis drugs. The aim of the study was to investigate the relationship of polymorphic gene variants of xenobiotic biotransformation metabolizing enzymes (NAT2 (590G>A (rs1799930), CYP2E1 (9896C>G (rs2070676), ABCB1 (3435T>C (rs1045642), GSTM1 (E/D), GSTT1 (E/D) with the risk of hepatotoxic reactions in patients with pulmonary tuberculosis. Material and methods. The logistic regression analysis method was used to predict the probability of hepatoxic reactions during specific anti-tuberculosis therapy. Results: 1 statistically significant model was obtained, which reflects the association with hepatotoxic reactions to anti-tuberculosis drugs of the TS genotypes or the TS gene (T allele) ABSV1 (rs1045642). Conclusion. Pharmacogenetic testing used in the study allows us to identify risk groups of patients with pulmonary tuberculosis according to the likelihood of hepatotoxic reactions, which may provide an individualized approach to the treatment of these patients in the future.https://www.antibiotics-chemotherapy.ru/jour/article/view/1064enzymes of xenobiotic biotransformationside effect of anti-tuberculosis drugshepatotoxicitylogistic regression analysis method |
| spellingShingle | М. А. Alymenko R. Sh. Valiev N. R. Valiev I. N. Tragira А. V. Polonikov N. Р. Balobanova A. V. Batishchev V. М. Kolomiets G. S. Mal S. N. Volkova V. V. Kozlov E. I. Suslikova E. V. Popova The effect of Polymorphism of the MDR1 (ABCB1) Gene on the Risk of Hepatotoxic Reactions in Patients with Pulmonary Tuberculosis Антибиотики и Химиотерапия enzymes of xenobiotic biotransformation side effect of anti-tuberculosis drugs hepatotoxicity logistic regression analysis method |
| title | The effect of Polymorphism of the MDR1 (ABCB1) Gene on the Risk of Hepatotoxic Reactions in Patients with Pulmonary Tuberculosis |
| title_full | The effect of Polymorphism of the MDR1 (ABCB1) Gene on the Risk of Hepatotoxic Reactions in Patients with Pulmonary Tuberculosis |
| title_fullStr | The effect of Polymorphism of the MDR1 (ABCB1) Gene on the Risk of Hepatotoxic Reactions in Patients with Pulmonary Tuberculosis |
| title_full_unstemmed | The effect of Polymorphism of the MDR1 (ABCB1) Gene on the Risk of Hepatotoxic Reactions in Patients with Pulmonary Tuberculosis |
| title_short | The effect of Polymorphism of the MDR1 (ABCB1) Gene on the Risk of Hepatotoxic Reactions in Patients with Pulmonary Tuberculosis |
| title_sort | effect of polymorphism of the mdr1 abcb1 gene on the risk of hepatotoxic reactions in patients with pulmonary tuberculosis |
| topic | enzymes of xenobiotic biotransformation side effect of anti-tuberculosis drugs hepatotoxicity logistic regression analysis method |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/1064 |
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