Enhancing docetaxel efficacy and reducing toxicity using biodegradable periodic mesoporous organosilica nanoparticles
Taxanes, such as docetaxel (DTX), are pivotal in cancer therapy, showcasing remarkable efficacy against various cancers, like breast, lung, and ovarian malignancies. However, DTX's efficacy is hindered by poor target specificity and significant adverse effects. Formulations containing DTX often...
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Elsevier
2024-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024161622 |
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| author | Ha Nguyen Van Linh Ho Thuy Nguyen Ngoc Xuan Dat Mai Anh Ha Nhat Trinh Le Thi Thu Anh Nguyen Thi Bao Ha Nguyen Thanh Minh Tri Le Tan Le Hoang Doan |
| author_facet | Ha Nguyen Van Linh Ho Thuy Nguyen Ngoc Xuan Dat Mai Anh Ha Nhat Trinh Le Thi Thu Anh Nguyen Thi Bao Ha Nguyen Thanh Minh Tri Le Tan Le Hoang Doan |
| author_sort | Ha Nguyen Van |
| collection | DOAJ |
| description | Taxanes, such as docetaxel (DTX), are pivotal in cancer therapy, showcasing remarkable efficacy against various cancers, like breast, lung, and ovarian malignancies. However, DTX's efficacy is hindered by poor target specificity and significant adverse effects. Formulations containing DTX often include polysorbate 80 and ethanol, exacerbating reactions like hypersensitivity and neurological disorders. Nanotechnology offers a promising avenue to address these challenges, aiming to enhance DTX's targeted delivery and solubility. Mesoporous silica nanoparticles (MSN), notably biodegradable periodic organosilane (BPMO), have emerged as promising carriers due to their stability, biocompatibility, and drug-loading capacity. BPMO's intracellular biodegradability reduces the risk of toxic accumulation. Compared to conventional MSN, BPMO particles exhibit superior characteristics, including size, surface area, and DTX loading ability. Moreover, cell line studies suggest BPMO's potential to mitigate DTX-associated adverse effects. These findings highlight BPMO nanoparticles' potential in improving DTX delivery, solubility, and reducing adverse effects, underscoring their significance in cancer therapy. |
| format | Article |
| id | doaj-art-9e6b2a0842054b37a2ae1c77dd03716f |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-9e6b2a0842054b37a2ae1c77dd03716f2024-11-30T07:11:53ZengElsevierHeliyon2405-84402024-11-011022e40131Enhancing docetaxel efficacy and reducing toxicity using biodegradable periodic mesoporous organosilica nanoparticlesHa Nguyen Van0Linh Ho Thuy Nguyen1Ngoc Xuan Dat Mai2Anh Ha Nhat3Trinh Le Thi Thu4Anh Nguyen Thi Bao5Ha Nguyen Thanh6Minh Tri Le7Tan Le Hoang Doan8University of Health Science (UHS), VNU-HCM, Ho Chi Minh City, Viet Nam; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet NamUniversity of Health Science (UHS), VNU-HCM, Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet NamCenter for Innovative Materials and Architectures (INOMAR), Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet NamUniversity of Health Science (UHS), VNU-HCM, Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet NamUniversity of Health Science (UHS), VNU-HCM, Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet NamUniversity of Health Science (UHS), VNU-HCM, Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet NamInstitute of Drug Quality Control Ho Chi Minh City (IDQC HCMC), Viet NamUniversity of Health Science (UHS), VNU-HCM, Ho Chi Minh City, Viet Nam; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet NamCenter for Innovative Materials and Architectures (INOMAR), Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet Nam; Corresponding author. Center for Innovative Materials and Architectures (INOMAR), Ho Chi Minh City, Viet Nam.Taxanes, such as docetaxel (DTX), are pivotal in cancer therapy, showcasing remarkable efficacy against various cancers, like breast, lung, and ovarian malignancies. However, DTX's efficacy is hindered by poor target specificity and significant adverse effects. Formulations containing DTX often include polysorbate 80 and ethanol, exacerbating reactions like hypersensitivity and neurological disorders. Nanotechnology offers a promising avenue to address these challenges, aiming to enhance DTX's targeted delivery and solubility. Mesoporous silica nanoparticles (MSN), notably biodegradable periodic organosilane (BPMO), have emerged as promising carriers due to their stability, biocompatibility, and drug-loading capacity. BPMO's intracellular biodegradability reduces the risk of toxic accumulation. Compared to conventional MSN, BPMO particles exhibit superior characteristics, including size, surface area, and DTX loading ability. Moreover, cell line studies suggest BPMO's potential to mitigate DTX-associated adverse effects. These findings highlight BPMO nanoparticles' potential in improving DTX delivery, solubility, and reducing adverse effects, underscoring their significance in cancer therapy.http://www.sciencedirect.com/science/article/pii/S2405844024161622DocetaxelNanomaterialCancerDrug deliveryBPMOMSN |
| spellingShingle | Ha Nguyen Van Linh Ho Thuy Nguyen Ngoc Xuan Dat Mai Anh Ha Nhat Trinh Le Thi Thu Anh Nguyen Thi Bao Ha Nguyen Thanh Minh Tri Le Tan Le Hoang Doan Enhancing docetaxel efficacy and reducing toxicity using biodegradable periodic mesoporous organosilica nanoparticles Heliyon Docetaxel Nanomaterial Cancer Drug delivery BPMO MSN |
| title | Enhancing docetaxel efficacy and reducing toxicity using biodegradable periodic mesoporous organosilica nanoparticles |
| title_full | Enhancing docetaxel efficacy and reducing toxicity using biodegradable periodic mesoporous organosilica nanoparticles |
| title_fullStr | Enhancing docetaxel efficacy and reducing toxicity using biodegradable periodic mesoporous organosilica nanoparticles |
| title_full_unstemmed | Enhancing docetaxel efficacy and reducing toxicity using biodegradable periodic mesoporous organosilica nanoparticles |
| title_short | Enhancing docetaxel efficacy and reducing toxicity using biodegradable periodic mesoporous organosilica nanoparticles |
| title_sort | enhancing docetaxel efficacy and reducing toxicity using biodegradable periodic mesoporous organosilica nanoparticles |
| topic | Docetaxel Nanomaterial Cancer Drug delivery BPMO MSN |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024161622 |
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